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《Chinese Journal of Hospital Pharmacy》 2006-01
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Atiasthmatic action of total alkaloid from Chelidouium majus

LUI Cui-zhe,TONG Ji-ming,ZHANG Li-min(Institute of Chinese Materia Medica,Chengde Medical College,Hebei Chengde 067000,China)  
OBJECTIVE To observe the antiasthmatic action of total alkaloid from Chelidouium majus.(TACM).METHODS Antiasthma action of TACM were investigated by models of asthma induced by histamine(His)-acetylcholine(Ach) or ovalbumin in guina-pigs and tests of isolated bronchoalveolar lavage fluid and of isolated intact trachea-capillary in guinea-pig.RESULTS TACM could prolong observably latent period of asthma induced by His and Ach or ovalbumin,and lower the number of animals occured asthma convulsion.TACM could increase observably capacity of isolated bronchoalveolar lavage fluid and inhibit the contraction,induced by His,which was of isolated trachea of guinea pig.CONCLUSION The results indicated that TAMC has markedly antiasthma action.
【CateGory Index】: R285.5
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1 WU Guo-Juan, ZHANG Zhong-Wen et al (Beijing Agricultural College,Beijing 102206);Antibacterial Effects of ChineseHerbal Medicines on Six Pathogenic Bacteriafrom Dairy Cows Mastitis[J];Journal of Beijing Agricultural College;2003-03
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