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《Chinese Journal of Hospital Pharmacy》 2006-10
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Preparation and phase diagram of sinomenine microemulsion

ZHANG Xian-zhou~(1),ZHU Hong-da~(2),XIA Li~(2),PAN Xi-gui~(1)(1.The Renmin Hospital of Wuhan University,Hubei Wuhan 430060,China;2.College of pharmacy,Wuhan University,Hubei Wuhan,430060,China)  
OBJECTIVE To study the optimum formulation and preparation of sinomenine microemulsion,and to establish a method to determine sinomenine.METHODS The optimum formulation was investigated by using titration to prepare the Pseudo-ternary phase diagram,testing the size distribution,stability and physico-chemical property of sinomenine microemulsion; sinomenine was determined by HPLC.RESULTS The stability of sinomenine microemulsion was good,average size was(35.67) nm,polydispersity index was (0.237).the average recovery was(99.33%),with RSD of(0.91%).CONCLUSION The formulation is reasonable,sinomenine microemulsion has good stability,the method for determining sinomenine is accurate and reliable
【CateGory Index】: R283;R286.0
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