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Study on the effects of Yuanhuzhitong formula on pain-related substances in formalin-induced pain model and dysmenorrhea rats

LIU Qun1,HUANG Xin2,SU Le-qun2(1.School of Pharmaceutical Sciences of Shandong University,Shandong Jinan 250012,China;2.Pharmaceutical Department,Shandong Province Qianfoshan Hospital,Shandong Jinan 250014,China)  
OBJECTIVE To investigate the effects of Yuanhuzhitong formula on prostaglandins,β-endorphin and monoamine transmitter of pain models of rats.METHODS Using tool drugs to measure analgesic effect of Yuanhuzhitong formula and detect the content of prostaglandins,β-endorphin and monoamine transmitter in formalin-induced pain model and dysmenorrhea rats.RESULTS Yuanhuzhitong formula had apparent analgesic effect in the experimental models;at the same time,the formula could reduce the content of PGF2α and the ratios of PGF2αand PGE2(P0.05)in the dysmenorrhea rats.In the formalin-induced pain model,the formula could reduce the content of β-endorphin and 5-HT,while there was no effect on the other monoamine transmitters.CONCLUSION Yuanhuzhitong formula alleviates pain through regulating the content of prostaglandins,β-endorphin and monoamine transmitter of pain models of rats.
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