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Reconstructed Model of Osteoporosis due to Kidney-Asthenia in Rats and Observation of Indices Related to the Model

shen Lin,et al(XieheHospital, Tongji Univesity,Wuhan)  
In this study a model of the osteoporosis due to kidney-asthenia was established by excision of the ovaries or the testes of rats at age of 10 months 3 months after ovariotomy or orchiectomy,the model showed many signs and pathological changes of the clinical postmenopausal and senile osteoporosis such as loss of bone mineral content rarefaction of bone with decalcification marked rises in level of serum alkaline phosphatase and ratio of fasting urinary calcium, phosphorus and hydroxyproline to creatinine. a decline in levels of serum estradiol and testosterone. decrease of mineralized cancellous bone density and enhancement of activity of osteoclost this article discussed the clinical and experimental significance of these indices.
【CateGory Index】: R274.911
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