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《Chinese Journal of Clinical Oncology》 2001-06
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Clinical Significance of Determination of Telomerase Actity in Gastric Cancers

Wang Xishan Wang Kuan Zhang Qi Department of Biology.Third Clinical Hospital of Harbin Medical University. Harbinfan et alvi  
Objective To study the expression of telomerase activity in gastric cancer and its adjacent tissues.and to explore the relationship between telomerase activity and clinicopathological factors. Methods Telomerase activity was examined quanitatively in 68 cases of gastric cancer and 40 specimens of its nontumor adjacent tissues using polymerase chain reaction PCR-based ELISA protocol. The results were analysed by measurement and enumeration data. Results Telomerase activity was positive in 60 88.24% of 68 gastric cancer tissues.whereas weak telomerase activity was detected only in 6 15% of 40 normal tissues P<0.01. And high telomerase activity was more often detected in node-positive gastric cancer tissues than that in node-negative ones χ2=4.87 u=2.01 P<0.05 Telomerase activity was associated with differentiation of gastric cancer χ2=4.34 u=2.17 P<0.05Telomerase activity was not statistically correlated with other clinicopathological factors. Conclusion Telomerase activity is associated with the carcinogenesis and progression of gastric cancer. Detection of telomerase activity is useful and helpful for diagnosis and radical resection of gastric cancer. Quantitative detection may be a wiser tool to discover the role of telomerase in malignant tumors.
【CateGory Index】: R735.2
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