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《Chinese Journal of Clinical Oncology》 2002-09
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A Study on Angiogenesis and Its Clinical Significance in Lung Neoplasms

Che Guowei Zhou Qinghua Tang Menglin et al Department of Thoracocardiac Sur gery,West China Hospital,Sichuan University,Chengdu  
Objective:To st udy the expression of VEGF,KDR and MVD and its clinical significance in lung ne oplasms.Methods:The expression of VEGF,KDR,and MVD were detect-ed in114l ung cancer tissues and paracancerous lesions and30benign pulmonary lesions by im-munohistochemical staining(LSAB Methods)Results:1)VEGF and KDR expressi on in lung can-cer tissues were significantly higher than those in paracancerou s and benign pulmonary tissues (P0.01);The same result was observed be tween paracancerous tissues and benign pulmonary tissues(P0.05).MVD in lung Cancer tissue was highly significantly higher than that in benign pul-mona ry tissues(P0.01).2)VEGF,KDR expression,and MVD were closely relate d to the size of primary cancer,lymph node status,P-TNM stages,grade of cell differentiation of lung cancer(P0.01).3)VEGF expression was the high est in the adenocarcinoma,the second was squa-mouscarcinoma,and the lowest wa s adenosqumous carcinoma.4)A positive correlation was found among VEGF,KDR a nd MVD in lung neoplasms.Conclusion:The results suggest that overex-pression of VEGF and KDR and MVD may play an important role in oncogenesis,development ,metastasis of lung cancer and serve as a tumor marker to evaluate the biologic al behavior of lung cancer.
【Fund】: 国家自然科学基金资助(编号:39670718)
【CateGory Index】: R734.2
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