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《Chinese Journal of Clinical Oncology》 2005-16
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Inhibitory Action of Transforming Growth Factor -β1 on Proliferation in Human Ovarian Cancer Cells

Zhang Yunyan Lou Ge Cheng Li et al Department of Gynecology, Tumor Hospital Affiliated to Harbin Medical University, Harbin  
Objective: To investigate the effect of transforming growth factor(TGF)- β1 on prolifer- ation in human Ovarian cancer cell line HO- 8910. Methods: Ovarian cancer cell line HO- 8910 was treated with TGF- β1 and assayed for growth response by MTT and FCM assay. Meanwhile, the expres- sion level of endogenous Smad7, p15, p21 and of c- myc genes mRNA as well as the protein induced by TGF- β1 was detected using semi- quantitative RT- PCR and Western blot, respectively. Results: The proliferation of HO- 8910 cells was significantly inhibited by TGF- β1. After exposure to TGF- β1, the expression level of p15 and of Smad7 in cells was profoundly up- regulated and the level of c- myc was down- regulated. Conclusions: TGF- β1 may affect the growth inhibition through regulation of the ex- pression levels of p15 and c- myc genes.
【Fund】: 黑龙江省科委重点攻关项目基金资助(编号:20020101)
【CateGory Index】: R737.31;
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