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《Chinese Journal of Clinical Oncology》 2006-08
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Empirical Studies on Quercetin for Inhibition of Proliferation ofhuman Uterine Cervix Cancer HeLa cells

Zhang Jie Lü Cai Zhang Ping-an et al Department of Urology, People's Hospital of Wuhan University, Wuhan  
Objective: To investigate inhibition of quercetin (Que) on cell proliferation of the human uterine cervix cancer HeLa cells. Methods: Colorimetric MTT-assay was used to measure the Inhibition ratio of Que on human HeLa cells. The proliferation cycle of HeLa cells was determined using flow cytometry. Results: Que 10-160umol/L inhibited the proliferation of HeLa cells with different ratios and showed the time- and dose-dependent relationships. The augment of G1 ratio in the proliferation cycle of Hela cells presents a dose-dependent manner. Conclusion: Que can inhibit the proliferation of Hela cells and might induce the apoptosis by restrained cell cycle at G1.
【Fund】: 湖北省计生委基金项目资助(编号:301140238)
【CateGory Index】: R737.33
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