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《Chinese Journal of Clinical Oncology》 2006-10
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hMAM Detection in Bone-Marrow Micrometastasis of Patients with Breast Cancer and Its Significance

Liu Yunjiang Liu Xianyi Liu WeiDepartment of Surgery, the No.4 Hospital of Hebei Medical University, Shijiazhuang  
Objective: To detect the expression of hMAM mRNA in bone marrow (BM) of patients with breast cancer and to determine the relationship between micrometastasis in BM and some molecular markers as well as the prognosis of breast cancer. Methods: The expression of hMAM mRNA in BM of patients with breast cancer was detected using RT-PCR. The expressions of ER, PR, Cath-D and VEGF in cancerous tissues were detected by immunohistochemical s-p method. Results: About 37.3% positive expression rate of hMAM mRNA in 102 patients with stage -Ⅰ andⅢ breast cancer was found. The expression of hMAM in BM was much higher in patients with ER(―)and ER(+)than that of ER(++?+++)(P0.001) and of PR (P0.05). hMAM expression in BM was significantly positive correlated with Cath-D (P0.05) and VEGF(P0.05). There was correlation between the expression of hMAM in BM and the distant metastasis in beast cancer (P0.05). Conclusions: The micrometastasis in BM is correlated with some tumor markers. The patients with positive expression of hMAM in BM have more chance of distant metastasis and may have poor prognosis. The detection of micrometastasis may be one of the targets to predict the prognosis of breast cancer.
【Fund】: 河北省科技厅科技攻关基金资助(编号:042761100)
【CateGory Index】: R737.9
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