Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Clinical Oncology》 2007-13
Add to Favorite Get Latest Update

The Expression and Correlation between β-catenin and Survivin in Rectal Carcinoma

Liu Feng Sun Lingyu Zhao Liang et al Department of Abdominal Surgery,the Tumor Hospital of Harbin Medical University,Harbin  
Objective: To evaluate the expression of β-catenin and survivin in rectal carcinoma and to determine if there is a correlation between the two. Methods: The expression levels of β-catenin and survivin were detected in 60 cases with rectal carcinoma and 20 cases with normal paraneoplastic rectal mucous tissues using immunohistochemistry. Results: β-catenin was positively expressed in the 20 normal cases while survivin was not expressed. In the rectal carcinoma tissues,the expression rate of survivin was 61.7%,and the expression rate of β-catenin was 66.7%. The abnormal expression rate of β-catenin did not correlate with gender,age,histological differentiation or 5-year survival rate (P0.05),but it correlated with lymph node metastasis (P0.01). Positive expression of survivin did not have a correlation with gender,age,histological differentiation or lymph node metastasis (P0.05),but it did correlate with the 5-year survival rate (P0.05). The abnormal expression of β-catenin and the positive expression of survivin had a significant positive correlation in rectal carcinoma (P0.01,r=0.388). Conclusion: Abnormal expression of β-catenin may activate the expression of survivin,which plays an important role in the carcinogenesis and progression of rectal carcinoma.
【Fund】: 黑龙江省卫生厅科研基金资助( 编号: GB03C601- 3)
【CateGory Index】: R735.37
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Song Yucheng Wan Desen Pan Zhizhong et al Department of Abdominal Surgery, Cancer Center, Sun Yat-Sen University, Guangzhou, Guangdong;The Expression and Clinicobiological Significance of Survivin in Dukes'C stage Colorectal Cancer[J];Chinese Journal of Clinical Oncology;2005-17
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 LI Jun-He1,2, HE Wen-Jing3, HE You-Jian1,2 1. State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China 2. Department of Medical Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P. R. China 3. Department of Inner Medicine, People's Hospital of Huadu District, Guangzhou, Guangdong, 510800, P. R. China;Expression and Clinical Significance of Survivin and Livin in Dukes' B Colorectal Cancer[J];Chinese Journal of Cancer;2007-05
2 ZHENG Hong ,LIU Yan-xue, SUN Bao-cun ,et al. Department of Biochemistry & Molecular Biology, Tianjin Cancer Hospital & Institute, Tianjin Medical University ,Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060;The Relationship Between Expression of Survivin mRNA and Protein with Apoptosis in Colorectal Carcinoma[J];The Practical Journal of Cancer;2007-04
3 ZHENG Hong, LIU Yanxue, SUN Baocun, WANG Jiacang Department of Biochemistry & Molecular Biology, Tianjin Cancer Hospital & Institute, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China;Relationship of Survivin Gene Expression and Apoptosis in Colorectal Carcinoma[J];Tianjin Medical Journal;2007-06
4 Junhe Li1, Wenjing He2, Youjian He3 1 Department of Oncology, The First Affiliated Hospital, Nanchang University, Nanchang 330006, China 2 Department of Blood Transfusion, The First Affiliated Hospital, Nanchang University, Nanchang 330006, China 3 Department of Medical Oncology, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China;The prediction of recurrence and survival of patients with Dukes’ B colorectal cancer after curative resection with immunohistochemical detection of Survivin and Livin expressions[J];中德临床肿瘤学杂志(英文版);2008-01
5 Zheng Hong Liu Yanxue Sun Baocun et al Department of Biochemistry and Molecular Biology, Cancer Hospital of Tianjin Medical University, Tianjin;The Relationship between mRNA and Protein Expression of Survivin and Apoptosis[J];Chinese Journal of Clinical Oncology;2006-15
6 He Jingdong Yang Kangqun Zhang Zhenshu et al Department of Oncology, Huai-an No. 1 Hospital Affiliated to Nanjing Medical University, Huai-an, Jiangsu;The Studies on Effect of Survivin siRNA for Apoptosis,Proliferation and Invasion of Colon Carcinoma Cell Line[J];Chinese Journal of Clinical Oncology;2006-23
7 Zou Lei Li Daotang Mu Dianbin et al Department of Thoracic Surgery, Shandong Tumor Hospital, Jinan;Correlation of Survivin and COX-2 expression and clinicopathologic factors in esophageal squamous cell carcinoma[J];Chinese Journal of Clinical Oncology;2007-12
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved