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《Chinese Journal of Clinical Oncology》 2011-24
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Expression and Correlation of S100A4 and MMP-9 in Laryngeal Squamous Cell Carcinoma

Yudong LIU~1,Shuai FENG~1,Juan ZHEN~2,Xing GUO~1 1 The Department of Otorhinolaryngology,First Affiliated Hospital of China Medical University,Shenyang 110001,China 2 The Department of Pathology,College of Basic Medical Sciences of China Medical University,Shenyang 110001,China  
Objective:To investigate the expression and significance of both S100A4 and MMP-9 in normal laryngeal tissues and laryngeal squamous cell carcinoma,and to discuss the roles of S100A4 and MMP-9 and their correlation in the process of laryngeal squamous cell carcinogenesis.Methods:The expressions of S100A4 and MMP-9 were determined using immunohistochemical S-P method.The relationship between the expressions of S100A4 and MMP-9 and their clinical pathological features were analyzed using the Western blot method.Result:The expression of S100A4 and MMP-9 significantly increased in laryngeal squamous cell carcinoma and was correlated with lymphatic metastasis.The immunohistochemical results showed an increasing tendency in the positive rate of S100A4 and MMP-9 expressions from normal laryngeal tissues(8.6%and 14.3%,respectively ) as well as from laryngeal squamous cell carcinoma(63.8%and 71.3%,respectively ).The Spearman's correlation test revealed that the S100A4 expression was significantly positively associated with MMP-9 expression in the 80 laryngeal squamous cell carcinoma specimens(P0.01,r_s = 0.440 ).Western blot results showed that expression of S100A4 and MMP-9 protein in laryngeal squamous cell carcinoma tissues was significantly higher than that in the non-tumorous counterparts,and the expression of MMP-9 protein in Hep-2 cells decreased after restraining the S100A4 protein.Conclusion:Both S100A4 and MMP-9 were abnormal in the development of laryngeal squamous cell carcinogenesis, and S100A4 gene suppression significantly decreased the expression of MMP-9.
【CateGory Index】: R739.65
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 CHEN Xiang-li1, WANG Lian-cai2, ZHANG Wang-gang1, CHEN Xiao-yan3, SUN Zhong-min3 1Department of Hematology, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710004, China; 2Department of Surgery, 3Department of Respiratory Diseases, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China;Correlations of S100A4 and MMP9 expressions to infiltration, metastasis and prognosis of non-small cell lung cancer[J];Journal of Southern Medical University;2008-07
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 GUO Suping1),MA Jun2),TANG Fu'ai1),LU Di1),DUAN Fangling2),GUO Qi1) 1)Department of Gastroenterology,the Second Affiliated Hospital,Zhengzhou University,Zhengzhou 450014 2)Digestive Disease Institute,the Second Affiliated Hospital,Zhengzhou University,Zhengzhou 450014;Relationship between prognosis and expressions of Galectin-9 and MMP-2 in esophageal squamous cell carcinoma tissue[J];Journal of Zhengzhou University(Medical Sciences);2012-06
2 LI Peng1,2,LIU Jiang-wei2(1 Medical College of Shihezi University Shihezi,Xinjiang 832000 China; 2 Department of Hepatobiliary Surgery,Urumuqi General Hospital of Lanzhou Military region Urumuqi 830000,China);Effect of S100A4 on Proliferation and Apoptosis of Tumor Cells[J];Progress in Modern Biomedicine;2011-04
3 Noemí Eiró,Francisco J Vizoso,Research Unit,Fundación Hospital de Jove,33290 Gijón,Asturias,Spain;Inflammation and cancer[J];世界胃肠外科杂志(电子版)(英文版);2012-03
4 LIU Jun-bin.(Department of General Surgery,Affiliated Hospital of Inner Mongolia Medical College,Hohhot 010050,China);Combined Analysis of S100A4 and S100A6 Expression in Gastric Cancer[J];Medical Recapitulate;2012-06
5 HUANG Xiang-wu,CHEN Zhi-qing,LIN Fang-yin,et al.Department of Pathology and General Surgery,Affiliated Hospital of Putian College,Fujian 351100,China;Expression and clinical significance of matrix met alloproteinase-9 and E-cadherin in pancreatic cancer[J];China Practical Medicine;2011-32
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 ZHOU Hai-kuan1, ZHAO Yong-bin2, ZHENG Shao-bin1, CHEN Tong1, MAO Xiang-ming1, QI Huan1, WU Rong-juan1 1Department of Urological Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; 2Department of Urological Surgery, General Hospital of Guangzhou Command, Guangzhou 510010, China;Association of S100A4 mRNA expression with differentiation and metastasis of renal cell carcinoma[J];Journal of First Military Medical University;2005-06
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