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《Chinese Journal of Clinical Oncology》 2011-24
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Expression and Correlation of S100A4 and MMP-9 in Laryngeal Squamous Cell Carcinoma

Yudong LIU~1,Shuai FENG~1,Juan ZHEN~2,Xing GUO~1 1 The Department of Otorhinolaryngology,First Affiliated Hospital of China Medical University,Shenyang 110001,China 2 The Department of Pathology,College of Basic Medical Sciences of China Medical University,Shenyang 110001,China  
Objective:To investigate the expression and significance of both S100A4 and MMP-9 in normal laryngeal tissues and laryngeal squamous cell carcinoma,and to discuss the roles of S100A4 and MMP-9 and their correlation in the process of laryngeal squamous cell carcinogenesis.Methods:The expressions of S100A4 and MMP-9 were determined using immunohistochemical S-P method.The relationship between the expressions of S100A4 and MMP-9 and their clinical pathological features were analyzed using the Western blot method.Result:The expression of S100A4 and MMP-9 significantly increased in laryngeal squamous cell carcinoma and was correlated with lymphatic metastasis.The immunohistochemical results showed an increasing tendency in the positive rate of S100A4 and MMP-9 expressions from normal laryngeal tissues(8.6%and 14.3%,respectively ) as well as from laryngeal squamous cell carcinoma(63.8%and 71.3%,respectively ).The Spearman's correlation test revealed that the S100A4 expression was significantly positively associated with MMP-9 expression in the 80 laryngeal squamous cell carcinoma specimens(P0.01,r_s = 0.440 ).Western blot results showed that expression of S100A4 and MMP-9 protein in laryngeal squamous cell carcinoma tissues was significantly higher than that in the non-tumorous counterparts,and the expression of MMP-9 protein in Hep-2 cells decreased after restraining the S100A4 protein.Conclusion:Both S100A4 and MMP-9 were abnormal in the development of laryngeal squamous cell carcinogenesis, and S100A4 gene suppression significantly decreased the expression of MMP-9.
【CateGory Index】: R739.65
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