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《Chinese Journal of Osteoporosis》 2008-03
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Effect of calcitonin on articular cartilage and subchondral bone in rat experimental osteoarthritis

LU Shengjun,YANG Shuhua.Department of Orthopedics,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China  
Objective To assess calcitonin,an inhibitor of bone resorption,on cartilage and subchondral bone in the rat anterior cruciate ligament transaction model,and assess the role of subchondral bone in the etiology of osteoarthritis(OA).Methods The rat anterior cruciate ligament transaction model was established.The rats were divided into two groups,the group ACLT,and group ACLT+CT.Group Sham was set up for control.After operation,rats in group ACLT+CT received subcutaneous injection of calcitonin every other day for the following 6 weeks.The same dose of normal saline was injected in group ACLT and group Sham.All rats were necropsied at 10 weeks.Paraffin sections were prepared.Toluidine blue stain and collagenⅡ immunohistochemistry stain was performed to assess the contents of proteoglycan and collagenⅡ.HE stain was used for subchondral bone histomorphometric analysis.Results Toluidine blue stain,collagenⅡ immunohistochemistry stain and bone histomorphometric analysis indicated that compared with group Sham,there was proteoglycan and collagenⅡloss in group ACLT.Increased subchondral bone formation and subchondral bone sclerosis were observed.Subcutaneous injection of calcitonin on early stage suppressed increased subchondral bone formation on advanced stage of OA rats,and reduced loss of proteoglycan and collagenⅡloss simultaneously.Conclusions Subchondral bone plays an important role in the pathogenesis of OA.Calcitonin could potentially be used for the treatment of OA.
【CateGory Index】: R684.3
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