Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Osteoporosis》 2014-12
Add to Favorite Get Latest Update

Study of the effect of salt-roast processing product of Eucommia ulmoides Oliv.on osteoporosis in ovariectomized rats

WENG Zebin;YAN Cuiping;WU Yu;CAI Baochang;CHEN Zhipeng;LI Weidong;Pharmacy College of Nanjing University of Chinese Medicine;Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing;Nantong Hospital of Traditional Chinese Medicine;  
Objective To evaluate the anti-osteoporosis effect of Eucommia ulmoides Oliv.and the effect of salt-roast processing product on the treatment efficacy in ovariectomized rats.Methods Forty female SD rats were divided into Sham group,OVX group,Eucommia ulmoides Oliv.group,and salt-roast processing Eucommia ulmoides Oliv.group.All the rats except in Sham group were ovariectomized.After 4 weeks of the operation,rats received oral Eucommia ulmoides Oliv.or its salt-roast processing product(4.0 g/kg·d) daily.The body weight of the rats was recorded.After a 12-w eek treatment,the serum calcium(S-Ca) and phosphorus(S-P) were measured.Serum ALP,osteocalcin(OCN),and estrogen(E2) were determined using ELISA kits.The uterus was weighed after execution of the rats and pathological examination was performed using HE staining.Bone mineral density of the bilateral femur was tested using dual-energy X-ray absorptiometry.Morphology of the trabecular and the number of the osteoblast were observed using HE staining.Microarchitecture of the trabecular bone was observed using micro-CT scan.Results Oral administration of Eucommia ulmoides Oliv.and the salt-roast processing product effectively inhibited ovariectomy-induced the body weight increase,increased S-Ca and E2,decreased S-P,ALP,and OCN.They increased BMD of the femur,improved microarchitecture of the trabecular bone,and increased the number the osteoblast.The long-term use of the drug had no stimulating effect on the uterus.Conclusion Eucommia ulmoides Oliv.and the salt-roast processing product have good therapeutic effect on ovariectomy-induced osteoporosis in rats,and the effect of salt-roast processing product is better than unroasted drug.
【Fund】: 江苏省高校自然科学研究重大项目(11KJA360001)
【CateGory Index】: R580
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 8 Hits
1 Zhang Yuanyuan,Zhang Rihua,Xue Yi,Liu Menglan,Huang Qiong,Liu Yun*(Department of Geratology,the First Affiliated Hospital,NJMU,Nanjing 210029,China);The relationship of obesity and estrogen and their impact on uterus[J];Acta Universitatis Medicinalis Nanjing(Natural Science);2013-08
2 Yang XZ, Chen XL, Wang DC Department of Orthopedics, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong Province, China;Lycopene associated with osteoblast, osteoclast and osteoporosis[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2007-49
3 BAO Jun-jie1,XIE Mei-lin2,ZHU Lu-jia2(1.the Second Affiliated Hospital of Soochow University,Suzhou,Jiangsu 215004,China;2.Dept of Pharmacology,Soochow University,Suzhou Jiangsu 215123,China);Treatment of osthol on osteoporosis in ovariectomized rats[J];Chinese Pharmacological Bulletin;2011-04
4 ZHU Xianjun,WEI Songquan.Department of Endocrinology,Sichuan Provincial People's Hospital,Chengdu 610072,China;Protective effect of quercetin on ovariectomy-induced bone loss in rats[J];Chinese Journal of Osteoporosis;2005-04
5 XIAO En,MENG Ping.Department of Gerontology,Southwest Hospital,Third Military Medical University,Chongqing 400038,China;The roles of bone metabolic biochemical markers in patients with osteoporosis:An update[J];Chinese Journal of Osteoporosis;2008-03
6 MIN Wen1,HUANG Gui-cheng1,HUA Yong-qin1,MA Yong1,HUANG Zheng-quan1,DU Bin2,SHEN Ji-rong2(1.Nanjing University of Traditional Chinese Medicine(TCM),Nanjing 210046,China;2.Jiangsu Province Hospital of TCM,Nanjing 210029,China);Empirical Studies on Treatment Effects of Bushen Tongluo Decoction in Osteoporosis Rats[J];Chinese Journal of Experimental Traditional Medical Formulae;2010-17
7 Wang Dawei, Gao Xiaoyan, Li Famei and Jiang Zhiming (Shenyang Pharmaceutical University, Senyang 110015);Effect of Eucommia ulmoides Oliv. Extracts on the Proliferation of Osteoblast-like Cells UMR106[J];Pharmacology and Clinics of Chinese Materia Medica;2000-04
8 Tang Quan-yong,Jia Zhi-yu,Zhao Yun-zhuan,Chen Biao,Zhang Rui,Yang Wei,Zhang Ying-huai Department of Oral and Maxillofacial Surgery,the 2nd Hospital of Hebei Medical University,Shijiazhuang 050000,Hebei Province,China;Caffeic acid inhibits osteoclast formation and expression of cathepsin K gene[J];Chinese Journal of Tissue Engineering Research;2012-46
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 QIAN Wei-na et al(Life Science College of Nantong University,Nantong,Jiangsu 226007);Effect of Eucommia ulmoides on Proliferation and Differentiation of Rats Bone Marrow Stromal Cells in vitro[J];Journal of Anhui Agricultural Sciences;2009-14
2 CHEN Zhi-neng1,SU You-xin2,YANG Lian-zi3,ZHENG Liang-pu2,SUN Zheng-you1 (1Xiaoshan Hospital of Traumatology and Orthopedics, Hangzhou 311261,China;2Fujian College of Traditional Chinese Medicine,Fuzhou 350003,China;3The Second People's Hospital of Fujian Province,Fuzhou 350003,China);The effect of different concentration of Qianggubao decoction extract on proliferation of osteoblastic cells cultured by high glucose in vitro[J];China Journal of Traditional Chinese Medicine and Pharmacy;2009-10
3 JIN Ling-yan,FAN Li,XU Jing-hong,LIN Jun(The First Affiliated Hospital,Medical College of Zhejiang University,Hangzhou 310003,China);Comparing Two Methods of Preparing Drug Microcapsules of Eucommiae Ulmoides Oliv[J];Journal of Materials Science and Engineering;2011-01
4 MA Yu-lin~1,DAI Ru-chun~2,SHENG Zhi-feng~2,et al 1.Department of Endocrinology,the affiliated Xiaolan People's Hospital of Nanfang Medical University,Zhongshan,528415, Guangdong,China;2.Institute of Metabolism and Endocrinology,The Second XiangYa,Central South University, Changsha,410011,China;Longitudinal changes of bone microstructure and biomechanical properties of vertebral trabeculae in OVX rats[J];Chinese Journal of Osteoporosis and Bone Mineral Research;2009-01
5 ZHAO Jin-dong,TANG Hai~*,BAO Li,et al Department of Orthopedics,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Change of microstructure of trabecular bone and its effect on bone biomechanics in OVX rat[J];Chinese Journal of Osteoporosis and Bone Mineral Research;2010-03
6 WEN Qin1,FENG Chen-chen1,DING Yi2.(1.Dept.of Periodontics,West China College of Stomatology,Sichuan University,Chengdu 610041,China;2.State Key Laboratory of Oral Diseases,Sichuan University,Chengdu 610041,China);Application of biochemical markers of bone turnover in the field of periodontology[J];International Journal of Stomatology;2010-01
7 QIAO Zhen1,2,QI Cai-hui1, LIU Xin1,YANG Mei-zi2, JIN Yong-jun1 (1.Department of Endocrinology,Affiliated Hospital of Binzhou Medical University,Yantai 264100,Shandong Provice,China;2.Department of Pharmacology,Binzhou Medical University,Yantai 264003,Shandong Provice,China);Effect of α-melanocyte-stimulating hormone on mouse serum bone-specific alkaline phosphatase and C-terminal cross-linking telopeptide of type 1 collagen in mouse serum[J];The Chinese Journal of Clinical Pharmacology;2013-01
8 SONG Yuan1,2,LI Sheng-hua1,2,HE Zhi-jun2,ZHANG Ya-wei2,ZHOU Ming-wang2 1Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;2Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,Gansu Province,China;Effect of icariin on osteoporosis in ovariectomized female rats[J];Journal of Chinese PLA Postgraduate Medical School;2012-04
9 HUANG Yu-dong,LIN Guo-ye,LIU Hang-tao,LI Ping-sheng(The First Department of Orthopedics,The First Affiliated Hospital of Fuzhou General Hospital,Nanjing Military Command,Fuzhou 351100,China);Comparison study on therapeutic effects of two kinds of treatment for primary osteoporosis[J];Practical Pharmacy and Clinical Remedies;2012-09
10 LIU Yue-yao1,ZHANG Kui-zhong2,SUN Gui-Cai2,XU Cong2,WU Bing-hua2,LING Qiang2(1.Department of Orthopaedics,Yihuang People's Hospital,Yihuang 344400,China; 2.Department of Orthopaedics,the Forth Affiliated Hospital of Nanchang University, Nanchang 330003,China);Treatment of Passive Smoking-induced Osteoporosis with Aucubin[J];Practical Clinical Medicine;2012-12
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 ;Method of fast establishment of rabbit osteoporotic model[J];Journal of Jilin University(Medicine Edition);2008-05
2 GAO Zhicheng, DENG Xiaodong, WANG Xinyu ,et al. Department of Pharmacy, Baoding Second Hospital, Hebei, Baoding 071057;Effect of compound Bugu capsules on the bone mineral density of ovariectonmized rats[J];Hebei Medical Journal;2004-01
3 WU Xiaoyu,TANG Quanyong,QU Pengfei,et al.Department of Oral and Maxillofacial Surgery,The Second Hospital of Hebei Medical University,Shijiazhuang 050000,China;The identification of the effective component in sweet potato extracts and its effect on the formation and differentiation of osteoclast[J];Hebei Medical Journal;2011-07
4 Guo Chun, Yan Yu-xian, Zhang Xi-zheng, Guo Yong, Song Mei, Wang Liang Institute of Medical Equipment, Academy of Military Medical Science, Tianjin 300161, China;Effects of mechanical strain strength on differentiation of mouse monocytes RAW264.7 into osteoclasts[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2009-37
5 TANG Quanyong,YANG Wei,JIA Zhiyu,et al. Department of oral and maxillofacial surgery,The 2nd hospital of Hebei Medical University,Shijiazhuang 050000;The inhibitory effect of sweet potato extracts on formation and differentiation of osteoclasts[J];Journal of Modern Stomatology;2008-01
6 CHEN Rong~1,XIE Mei-lin~1,ZHOU Jia~2(1.Dept Pharmacology,Medical College of Suzhou University,Suzhou Institute ofChinese Meteria Medica,Suzhou 215007,China; 2.Xian Green Spring Natural Product Co. Ltd, Xian 710075,China);Experimental study of osthole on inhibition of thrombosis and platelet aggregation[J];Chinese Pharmacological Bulletin;2005-04
7 ZHANG Yan1,2,XIE Tao3,XUE Jie1,ZHU Lu-jia1,HUA Yi-nan1,XIE Mei-lin1,GU Zhen-lun1(1.Dept of Pharmacology,Medical School of Soochow University,Suzhou Jiangsu 215123,China;2.Maternal and Child Health Hospitalof Wuxi,Wuxi Jiangsu 214002,China;3.Faculty of Clinical Medicine,Binzhou Medical College,Binzhou Shandong 264003,China);Study of the effects of osthole on blood estradioland lipase in animals and their relationship[J];Chinese Pharmacological Bulletin;2007-11
8 pro osteoclastic activities 1 ZHANG Jun Ping, WU Tang Ming, HU Zhen Lin, QIAN Ding Hua ( Research Laboratory of Natural and Synthetic Drugs, School of Pharmacy, Second Military Medical University, Shanghai 200433, China );Inhibitory effect of quercetin on tumor necrosis factor and interleukin 1β[J];中国药理学报(英文版);1996-03
9 BAO Jun-jie~1,XIE Mei-lin~(1*),ZHOU Jia~2,ZHU Lu-jia~1(1.Department of Pharmacology,Suzhou University,Suzhou 215007,China;2.Xi'an Green Spring Natural Product Co.Ltd,Xi'an 710075,China);Prevention of Osthol on Osteoporosis in Ovariectomized Rats[J];Chinese Pharmaceutical Journal;2006-03
10 崔伟,刘成林;Function of osteoclasts cultured in vitro[J];Chinese Journal of Osteoporosis;1997-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved