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《CHINESE JOURNAL OF SURGERY OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE》 2000-03
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Effect of San Shen Powder on Adhesion Molecule in Patients with Lung Carcinoma

Li Shuqi,Qi Xin,Pei Yingxia,et al. Guang An Men Hospital of the Chinese Academy of Traditional Chiese Medicine(100053)  
Objective:To explore the inhibiting mechanisms of traditional Chinese medicine San Shen Powder(SS)on lung carcinoma metastasis.Methods:Controlled prospective study was adopted to investigate the effect of SS and chemotherapy on the expression of adhesion molecule,CD 44 ,CD 49 ,CD 31 and circulating endothelial cell(CEC)in the advanced non small cell lung cancer patients.Results:This study demonstrated preliminarily adhesion molecules CD 32 ,CD 44 ,CD 49 ,and CEC expression increase was correlated with metastasis in the advanced non small cell lung cancer.San Shen Powder could reduce this expression and the amount of CEC,protect endothelial entity,enhance patients lift quality significantly compared with the chemotherapy control group.Conclusion:San Shen Powder could reduce expression of adhesion molecules CD 44 ,CD 31 ,CD 49 in the advanced lung cancer patient,reduce amount of CEC and protect endothelial entity.San Shen Powder could protect against cancer cell metastasis.
【Key Words】: lung cancer adhesion molecule metastasis
【CateGory Index】: R273
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