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《Chinese Journal of Surgery of Integrated Traditional and Western Medicine》 2004-03
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Perioperative Administration of Astragalus Injection on Liver and Renal Function in Patients with Obstruction Jaundice

Feng Wenming,Bao Ying,Fei Maoyun,et al. Department of Hepatobiliary Surgery,Frist Hospital of Huzhou,Huzhou,(313000),China  
Objective To examine the effects of perioperative administration of astragalus injection on liver and renal function in patients suffering from obstructive jaundice Methods Sixty-four patients admitted for surgical intervention on obstructive jaundice were divided into two groups:the experimental group,34 patients,being administered astragalus injection postoperatively for 7-10 days,and the control group,30 patients with conventional treatment.Results At the third postoperative day,the levels of creatinine(Cr)and aspartate aminotransferase(AST)were significantly higher than those preoperatively,the levels of total bilirubin(TBIL)and creatinine clearance rate(Ccr) were lower.On day 7,TBIL content was lower than that preoperatively,the Cr and AST levels showed no statistical differences,but Ccr was lower in the control group,endothelin (ET-1) was lower than that preoperatively in the experimental group.The levels of Cr and AST significantly decreased,the Ccr significantly increased in the experimental group as compared with those in the control group. Conclusion Perioperative administration of astragalus injection showed beneficial effects on liver and renal function by reducing ET-1 in patients suffering from obstructive jaundice.
【CateGory Index】: R657.4
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