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《Chinese Journal of Surgery of Integrated Traditional and Western Medicine》 2014-03
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Anesthesia Effects of Different anesthetic in Myocardial Infarction Experiment Model

JIANG Wen-chen;GUI Xiao-chen;LI ping;Department of Anesthesiology, Tianjin Hospital;  
ObjectiveTo investigate the anesthesia effects of different anesthetics in myocardial infarctionmodels of rats.MethodsSixty adult male Wistar rats were randomly divided into 5 groups: chloral hydrategroup, pentobarbital sodium group and ketamine group,ether group and ether compound ketamine anesthesiagroup, each group of 12 rats. The narcotic effect indexes of rat mortality, anesthesia and anesthesia time were ob-served respectively.ResultsThe mortalityether in the ether group was highest(33%), followed by pentobarbi-tal sodium group(25%), and the ketamine group(25%), the chloral hydrate group and ether compound ketamineanesthesia group was the lowest(16.67%). For the anesthesia index, the anesthesia compound group was moststable, followed by the chloral hydrate group. For the anesthesia time, the ether anesthesia induction time was114 seconds, and duration time 284 seconds, while the pentobarbital sodium, ketamine anesthesia induction timewas longer, and duration time was more than 400 seconds, chloral hydrate induction time was 422 seconds, dura-tion time was 6785 seconds;in ether compound ketamine anesthesia, anesthesia induction time 194 seconds, du-ration time 4710 seconds.ConclusionFor chloral hydrate or ether compound anesthesia and ketamine, theinduction time is shorter, duration time is moderate, more suitable for building model operation of myocardial in-farction.
【Fund】: 科技部重大专项子课题(2009ZX09502-020-002)
【CateGory Index】: R614
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