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《Chinese Journal of Surgery of Integrated Traditional and Western Medicine》 2015-03
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Experimental Study of Treatment of Steroid-induced Avascular Necrosis of Femoral Head with Bushen Huoxue Recipe

ZANG Hong-min;LI Qing-tao;Si Ji-gang;Department of Orthopedics, Zibo Central Hospital;  
ObjectiveTo explore the mechanism of steroid-induced avascular necrosis of femoral headtreated by Bushen Huoxue Recipe.MethodsTwenty-four rabbits were randomly divided into three groups:the control group, the sham control group and the Traditional Chinese Medicine group. Acetic acid hydropredni-sone 8 mg/Kg via gastrogavage was given after establishment of the animal model for 8 weeks. All rabbits werekilled and serum lipid, X-ray film, the number of empty lacuna and bone mineral density of femoral head wereobserved and measured.ResultsIn the Traditional Chinese Medicine group, levels of total cholesterol was(2.23±0.34)mmol/L, triglyceride was(1.53±0.21)mmol/L, the rate of empty lacuna was(23.35±1.43)%. Allthese values were lower than those in the sham control group. Bone mineral density of femoral head[(0.539 ±0.038)g/cm2] and the amount of new blood vessels(7.4 ± 2.1)in the Traditional Chinese Medicine group werehigher than those in the sham control group.ConclusionBushen Huoxue Recipe can reduce serum lipid, in-crease bone mineral density and absorption of necrosis of bone, and promote formation of new bone. The experi-ment provides a theoretical basis for treatment of necrosis of the femoral head.
【CateGory Index】: R274.9
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