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《China Journal of Chinese Materia Medica》 2003-12
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Experimental Study of Puerarin Injection on the Hemorheology in Acute Blood-stasis Model Rats

PAN Hong-ping, YANG Jia-zhen, LI Lu-li, YI Fei, HUANG Zhuo-qun, HUANG Kai-wen (People's Hospital of Guangxi Autonomous Region, Nanning 530021, Guangxi, China)  
Objective: To observe the effect of Puerarin Injection on the hemorheology in acute blood-stasis model rats. Method: The acute blood-stasis model rats were made by being soaked in ice water afer being injected adrenaline hydrochloride injection in a major dose.The changes of viscosity of whole blood and plasma,blood yield stress, erythrocyte aggregation and the maximum rate of platelet aggregation in the acute blood-stasis model rats were measured with Auto-Viscometer,and then the influence of Puerarin Injection on the hemorheology in the model rats was investigated. Resuit: The viscosity of whole blood and plasma, and blood yield stress in the acute blood-stasis model rats were significantly higher than those in the normal control group( P 0.01, P 0.05).Both the high dose and the low dose of Puerarin Injection could reduce the viscosity of whole blood and plasma, blood yield stress and the maximum rate of platelet aggregation in the acute blood-stasis model rats( P 0.01, P 0.05). The high dose could also reduce the erythrocyte aggregation and the deformed Index of red blood cell( P 0.05). Conclusion: Puerarin Injection can ameliorate the hemorheology in acute blood-stasis model rats,and it has a dose-response relationship.
【Fund】: 广西壮族自治区卫生厅医药卫生科研课题 (合同号 :Z2 0 0 10 72 )
【CateGory Index】: R285.5
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