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《China Journal of Chinese Materia Medica》 2004-11
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Simultaneous determination of 4 anthraquinones in Kuhuang injection by RP-HPLC

WU Yong-jiang, CHEN Jian-jun, CHENG Yi-yu (Department of Chinese Medicine Science and Engineering, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310027) [  
Objective: To develop a new high-performance l iq uid chromatographic method for simultaneous quantitative determination of 4 anth raquinones in Kuhuang injection. Method: The chromatographic s eparation was performed on a Lichrospher C 18column (4.6 mm×250 mm,5 μ m,), A linear gradient elution of A (CH 3COOH∶H 2O=1∶100) and B (CH 3COOH ∶H 2O∶CH 3CN=1∶20∶80) was used. The flow rate was 0.8 mL·min -1an d column temperature was set at 35 ℃. The UV detection wavelength was set at 2 54 nm. Result: The recoveries of rhein, emodin, chrysophano l and physcion were 98.9%, 100.5%, 102.5% and 99.0%, respectively. Their linear ranges were 0.087 5~1.75 μg for rhein, 0.082 5~1.65 μg for emod in, 0.159~3.17 μg for chrysophanol and 0.052 5~1.05 μg for physcion, r espectively. Conclusion: The method was accurate, repeatable and suitable to determine the contents of 4 anthraquinones in Kuhuang injectio n. [
【Fund】: 国家重点基础研究发展规划项目 (973计划 )资助(G19990 944 0 5 )
【CateGory Index】: R286
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