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《China Journal of Chinese Materia Medica》 2006-15
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Review about mechanisms of anti-cancer of Solanum nigrum

AN Lei~(1),TANG Jin-tian~(2),LIU Xin-min~(1),GAO Nan-nan~(1) (1.Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100094,China; 2.Institute of Medicinal Physics & Engineering,Tsinghua University,Beijing 100084,China)  
This paper gave a brief introduction of the effect of Solanum nigrum on anti-cancer.The experimental results showed that the total alkaloid isolated from S.nigrum interfered structure and function of tumor cell membrane,disturbed the synthesis of DNA and RNA,changed the cell cycle distribution,so that total alkaloids could play in inhibabition to tumor cells,while the glycoprotein(150×10~3) isolated from S.nigrum might have shown anti-cancer abilities by blocking the anti-apoptotic pathway of NF-κB,activating caspase cascades reaction and increasing the production of nitric oxide.
【Fund】: 国家重点基础研究发展规划(973)项目(2004CB720301)
【CateGory Index】: R285.5
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