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《China Journal of Chinese Materia Medica》 2008-05
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Experimental study of Solanum nigrumon inhibiting angiogenesis in chick chorioallantoic membrane

XU Yang1, PAN Rui-le1, CHANG Qi1, Qin Meng1, LIU Yan2, TANG Jin-tian3(1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China; 2. Beijing University of Chinese Medicine, Beijing 100029, China;3. Institute of Medical Physics & Engineering, Tsinghua University, Beijing 100084, China)  
Objective: To study the inhibitory effect ofSolanum nigrumon angiogenesis. Method: We examined the effects ofS. nigrumon angiogenesis in the chick chorioallantoic membrane (CAM) model. On day 7 of chick embryo incubation, three concentrations ofS. nigrumaqueous extracts were applied to CAMs, and their effects were evaluated on day 9. Result: The angiogenesis area was significantly smaller in the CAM treated withS. nigrumthan that in the control group (P0.001). Pathology analysis indicated that less angiogenesis occurred in the tissue of CAM under the filter paper treated withS. nigrumand the structure of large arteries was destroyed. The surrounding CAM showed a few angiogenesis formation. However, in the control group, a number of angiogenesis were observed. Conclusion:S. nigrumcould inhibit the angiogenesis on CAM.
【Fund】: 国际科技合作重点项目计划(2004CB720301)
【CateGory Index】: R285
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【Secondary References】
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1 SUN Yuewen LIANG Gang TANG Yanxia Guangxi Medical University, Nanning 530021, China;Antiangiogenesis effect of four Chinese herbal to allantocherion of chick embryo[J];中国当代医药;2013-09
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