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《China Journal of Chinese Materia Medica》 2008-16
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Antioxidant xanthones from Securidaca inappendiculata

KANG Wen-yi1,2,LI Cai-fang1,2,SONG Yan-li 1,2(1.Institute of Natural Products,Henan University,Kaifeng 475004,China;2.Pharmaceutical College of Henan University,Kaifeng 475004,China)  
Objective: To study the antioxidant constituents from the roots of Securidaca inappendiculata.Method: The bioassay-guided isolation of antioxidant constituents was carried out by the column chromatographic techniques.The combination of IR,MS,NMR and 2D-NMR spectroscopics methods was used to identify their structures.Result: Two new xanthones,1,2,5-trihydroxy-6,8-dimethoxy-9H-xanthen-9-one(1),1,5-dihydroxy-2,6,8-trimethoxy-9H-xanthen-9-one(2),along with seven known ones,3,8-dihydroxy-1,4-dimethoxy-9H-xanthen-9-one(3),4,6-dihydroxy-1,5,7-trimethoxy-9H-xanthen-9-one(4),7-hydroxy-1,2,3,8-tetramethoxy-9H-xanthen-9-one(5),1,7-dihydroxy-9H-xanthen-9-one(6),4-hydroxy-3,7-dimethoxy-9H-xanthen-9-one(7),1,7-dimethoxy-9H-xanthen-9-one(8) and aucuparin(9),were isolated from the roots of S.inappendiculata.Conclusion: Compounds 1 and 2 were new xanthones,and compound 3 was isolated as a natural product for the first time,and compounds 4 and 6 were isolated for the first time from this genus.The antioxidant activities of all compounds were evaluated by ABTS,FRAP and DPPH assays respectively.Compound 9 showed significant activity by the ABTS and FRAP assays.Compound 1 showed significant activity with IC50 value of 0.31 mg·L-1 in DPPH assay.Scavenging capacity of all compounds determined by all assays were well correlated between ABTS and FRAP assay(r=0.955 5).
【Fund】: 国家自然科学基金项目(30500646);; 河南省卫生厅艾滋病科技攻关项目(2006038);; 河南省教育厅基础研究计划项目(2007360005)
【CateGory Index】: R284
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