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《China Journal of Chinese Materia Medica》 2012-07
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Chemical constituents contained in seeds of Notopterygium franchetii

ZHANG Yanxia1,JIANG Shunyuan2,XU Kaijie1,SHI Haili1,ZHOU Yi2,DENG Wenlong2,DING Lisheng1,PENG Shulin1*(1.Chengdu Institute of Biology,Chinese Academy of Sciences,Chengdu 610041,China; 2.Sichuan Key Laboratory of Quality and Innovation Research of Chinese Materia Medica, Sichuan Academy of Chinese Medicine Sciences,Chengdu 610041,China)  
Objective: To study the chemical constituents from the seeds of Notopterygium franchetii.Method: Ethanol extracts of seeds N.franchetii were separated and purified by such methods as normal and reversed phase column chromatographies and thin-layer chromatography and structurally elucidated by MS and NMR evidences.Result: Twenty nine compounds were separated,they were isoimperatorin(1),β-sitosterol(2),phellopterin(3),bergapten(4),N-tetra,hexa,octacosanoylanthranilic acid(5-7),daucosterol(8),oxypeucedanin hydrate(9),umbelliferone(10),demethylfuropinnarin(11),(2S,3S,4R,8E)-2-[(2′R)-2′-hydroxydoco,trico,tetraco,entaco,hexaco sanosylamino]-octadecene-1,3,4-triol(12-16),(-)-oxypeucedanin(17),diosmetin(18),bergaptol-O-β-D-glucopyranoside(19),nodakenin(20),1′-O-β-D-glucopyranosyl-(2R,3S)-3-hydroxynodakenetin(21),uracil(22),decuroside V(23),8-O-β-D-glucopyranosyl-5-hydroxypsoralen(24),8-O-β-D-glucopyranosyl-5-methoxylpsoralen(25),diosmin(26),alaschanioside C(27),kynurenic acid(28) and mannitol(29).Conclusion: All of these compounds were separated from the seeds of N.franchetii for the first time.Of them,18,22,26 and 29 were firstly obtained from genus Notopterygium.
【Fund】: 国家“重大新药创制”科技重大专项(2009ZX09308-002 2009ZX09103-439);; 国家重点基础研究发展计划(973)项目(2007CB512604);; 国家中医药管理局科技专项(06-07ZP42)
【CateGory Index】: R284
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