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《China Journal of Chinese Materia Medica》 2013-08
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Advance in studies on anti-tumor activity of polysaccharides in latest five years

LIN Jun1,LI Ping1,CHEN Kao-shan1,2*(1.Department of Pharmacology,Wannan Medical College,Wuhu 241000,China; 2.School of Life Sciences,Shandong University,Ji′nan 250100,China)  
Polysaccharides widely exist in animals,plants,microorganisms,and possess various biological activities including anti-tumor,anti-virus,anti-oxidant and immunomodulatory.polysaccharides shows notable anti-tumor activity and less toxicity,and becomes a hotspot in the studies of anti-tumor drugs.Therefore,there is huge potential for developing polysaccharides into a novel anti-tumor medicine.This article summarized polysaccharides derived from animals,plants,microorganisms which have significant anti-tumor effect in the latest 5 years;findings indicate that polysaccharides show the anti-tumor effect directly by inducing tumor cell apoptosis and indirectly as an immunoenhancement.This article also looks into the future of studies on anti-tumor activity of polysaccharides.
【Fund】: 国家高技术研究发展计划(863)项目(2012AA021501);; 国家重点基础研究发展计划(973)项目(2012CB822102);; 皖南医学院校中青年科研项目(WK201111)
【CateGory Index】: R273
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