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《China Journal of Chinese Materia Medica》 2013-13
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Study on directional separation of picroside Ⅱ from extract of traditional Chinese medicine by molecularly imprinted technology

YI Li-na1,2,LI Ke-Qin1,WANG Qiu-juan2,LIU Qing-shan1,GUO Qing-long2(1.China Research Center for Traditional Minority Medicine,Minzu University of China,Beijing 100081,China; 2.Pharmacology Department of China Pharmaceutical University,Nanjing 210009,China)  
Picroside Ⅱ,separated from Chinese herbal medicine,is an active compound with neroprotective activity.Molecularly imprinted polymers(MIPs) have high affinity toward template molecules synthesized by molecularly imprinted technology for its specific combined sites,which can overcome the shortcomings of traditional separation methods,such as complex operation and low efficiency.In this paper,MIPs were prepared by precipitation polymerization with picroside Ⅱ as the template molecule,1-vinylimidazole(1-Vinyl) as functional monomer,ethylene glycol dimethacrylate(EDMA) as cross-linker.The morphology of MIPs was characterized by scanning electronmicroscope(SEM) and its static adsorption capacity was measured by the scatchard equation.The results showed that picroside Ⅱ MIPs have spherical shape,and most of them are uniform in size.Furthermore,the maximum binding capacity(Qmax) of MIPs is 3.02 mg·g-1,higher than that of non-imprinted polymers(NIPs).This result indicated that picroside Ⅱ MIPs with good morphology and high targeted affinity toward the template molecules can be prepared by precipitation polymerization,which can be used to separate picroside Ⅱ and its analogies from extract of Chinese herbal medicine.In addition,this method has the advantages of good environment and simple operation,which might offer a novel method for the efficient separation of picroside Ⅱin the traditional herbal medicines.
【Fund】: 国家自然科学基金面上项目(81173657)
【CateGory Index】: R284
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 YI Li-na1,2,YIN Xiao-ying3,JIANG Yi-fan3,LIU Qing-shan(1.China Minority Traditional Medical Research Center,Minzu University of China,Beijing 100081,China; 2.Cardiovascular Pharmacology Department,China Pharmaceutical University,Nanjing 210009,China; 3.College of Pharmacy,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China);Application of molecularly imprinting technology in efficient separation of active components from Traditional Chinese herb[J];Journal of International Pharmaceutical Research;2012-04
2 LIU Qingshan1,ZHANG Ziqian1,FANG Liang2,JIANG Yifan3,YIN Xiaoying 3(1.National Center of China for Minority Traditional Medical Research,Minzu University of China,Beijing 100081,China; 2.Soochow University,Suzhou 215006,China; 3.Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China);Application of network pharmacology and high through-put technology on active compounds screening from traditional Chinese medicine[J];China Journal of Chinese Materia Medica;2012-02
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 JIANG Hui;LI Ke-qin;LI Xu;GU Li-li;ZHUANG Shu-juan;LIU Qing-shan;Department of Ophthalmology and Otolaryngology,Affiliated Hospital of Taishan Medical College;China Minority Medicine Research Center,Minzu University of China;;Protective effects of effective components group of Medicine Terminalia Fruit on experimental liver fibrosis[J];Journal of International Pharmaceutical Research;2013-05
2 YI Li-na1, LIU Qing-shan2, WANG Qiu-juan1, GUO Qing-long1*(1.Physiology Department of China Pharmaceutical University,Nanjing 210009,China;2.MINZU University of China,State Nationalities Affairs Commission and Department of Educational Key Lab of Minority Traditional Medicine,Beijing 100081,China);Preparation of Picroside Ⅱ Molecularly Imprinted Polymers by Precipitation Polymerization[J];Lishizhen Medicine and Materia Medica Research;2013-05
3 WANG Jun-ming;MIAO Ming-san;QU Ling-bo;ZHANG Yue-yue;CUI Ying;School of Pharmacy,Henan University of Traditional Chinese Medicine;College of Chemistry and Molecular Engineering,Zhengzhou University;Third Grade Pharmacology Laboratory of State Administration of Traditional Chinese Medicine,Henan University of Traditional Chinese Medicine;;Application Status and Proposals of Network Pharmacology in Study on Traditional Chinese Medicine[J];Lishizhen Medicine and Materia Medica Research;2013-09
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