Study on material base of Corydalis Rhizoma
YANG Xin-bao;YANG Xiu-wei;LIU Jian-xun;Research Center,Xiyuan Hospital,China Academy of Chinese Medical Sciences;Beijing University of Chinese Medicines;State Key Laboratory of Natural and Biomimetic Drugs,Department of Natural Medicines,School of Pharmaceutical Sciences,Peking University;
Corydalis Rhizoma,the dried tuber of Corydalis yanhusuo( Papaveraceae) distributed traditionally mainly in southeastern and now cultivated in northwestern and other district in China,is one of the commonly used and well-known traditional Chinese medicine. It has been widely used to treat spastic pain,abdominal pain,pain due to injury,and promote blood circulation. Its main chemical constituents were alkaloids,which were divided into the two types of protoberberines and aporphines. Among them,some alkaloids were found to elicit profound effects on the dopaminergic system in the central nervous system,which plays an important role in regulating nociception. In this article,the chemical composition and structure-types,new methods of qualitative and quantitative analysis as well as characteristics of biotransformation,absorption,distribution,metabolism,excretion,pharmacokinetic,and drug-drug interaction for the alkaloids were revealed. These results would greatly contribute to the establishment of bioactive material base of Corydalis Rhizoma.