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《China Journal of Chinese Materia Medica》 2014-13
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Identification of phenylpropanoids in Ciwujia injection by HPLC-MS

HUANG Jing;SHAO Qing;XIANG Yan-hua;GE Zhi-wei;FAN Xiao-hui;Department of Chinese Medicine Science & Engineering,Zhejiang University;ZBD Pharmaceutical Company;  
There are reports about the chemical compounds of Ciwujia herbs,but with no study report about the chemical material basis of Ciwujia injection(CWJI). In this study,LC-MSnand LC-Q-TOF-MS techniques were adopted for a qualitative analysis on phenylpropanoids in CWJI. The UltmateTMXB-C18column(4. 6 mm × 250 mm,5 μm) was adopted and eluted with the mobile phase of 0. 5% formic acid-water and acetonitrile,with the flow rate at 0. 8 mL·min-1and the column temperature at 20 ℃. Based on the data of high-resolution and multi-stage MS,control products and literatures,altogether 54 phenylpropanoids were identified in Ciwujia Injection,including 34 phenylpropanoids,16 ligans and 4 coumarins. Among them,28 were reported for the first time in Ciwujia,and 14 compound structures were identified in comparison with the control products. The method established in this study could be used to simply and rapidly identify phenylpropanoids in CWJI. The findings provide scientific data for defining the chemical material basis of CWJI.
【Fund】: 国家重点基础研究发展计划(973)项目(2012CB518405)
【CateGory Index】: R284.1;O657.63
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