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《China Journal of Chinese Materia Medica》 2015-09
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Study on effect of oligochitosan in promoting intestinal absorption of protoberberine alkaloids in extracts from Corydalis saxicola total alkaloids

LI Xin-yang;XIE Hui;LU Tu-lin;SHI Yue-jiao;ZHANG Xing-de;LIU Ting;Nanjing University of Chinese Medicine;  
Objective: To investigate the effect of oligochitosan in promoting intestinal absorption of protoberberine alkaloids in extracts from Corydalis saxicola total alkaloids. Method: The in vitro single-pass intestinal perfusion model in rats was established to study the changes in absorption kinetic parameters of dehydrocavidine,berberine hydrochloride and palmatine chloride in C. saxicola total alkaloids after the addition of different concentrations oligochitosan and evaluate the effect of oligochitosan in promoting intestinal absorption of the drugs. Result: The concentration of oligochitosan had different effects on the absorption rate constant( Ka) and apparent permeability coefficient( Peff) of the three active component in rat intestines. Kaand Peffin 0. 5% oligochitosan group significantly increased,indicating a stronger effect in promoting the absorption. Conclusion: Oligochitosan has a certain effect in promoting the intestinal absorptions of protoberberine alkaloids in C. saxicola total alkaloids.
【Fund】: 江苏高校优势学科建设工程项目
【CateGory Index】: R285.5
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