Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《China Journal of Chinese Materia Medica》 2015-21
Add to Favorite Get Latest Update

Experimental study on effect of model on hepatic fibrosis with Aralia chinesis

HUANG Miao;LIU Xin;DONG Lei;SHI Hai-tao;LIU Ya-ping;LIU Chao;Department of Digestive Diseases,Second Affiliated Hospital of Xi'an Jiaotong University;  
[Abctract]Hepatic fibrosis models were induced by CCl_4 in rats.To explore vascular endothelial growth factor(VEGF),transforming growth factor-beta1(TGF-β1) mRNA expression and bcl-2,Bax protein expression levels of intervention and explore the mechanism of the Aralia chinesis anti-hepatic fibrosis.Sixty male Sprague-Dawlley(SD) rats were randomly divided into six groups:nomal group,model group,high-dose(10 mL·kg~(-1)),medium-dose(7.5mL·kg~(-1)),low-dose(5.0mL·kg~(-1)) of A.chinesis treated group and colchicine treated group.The change of liver histopathology was observed by HE and Masson staining.The mRNA of VEGF,TGF-β1 were detected by RT-PCR.The protein of Bcl-2 and Bax were detected by Western blot.In the model group liver cell obvious degeneration,necrosis,a large number of collagen fibers of the cable hyperplasia,part visible pseudolobule formation.A.chinesis large,medium,low-dose group and colchicine group liver cell degeneration and necrosis reduced A.chinesis small,medium,and highdose group was gradually reduced trend and A.chinesis large,middle dose group degree of reduction is particularly significant.Compared with model group,A.chinesis of large,medium and small dose group and colchicine group VEGF mRNA expression,A.chinesis of large,medium-dose group TGF-β1 mRNA expression reduce(P 0.05);compared with colchicine group,A.chinesis of large,middle dose group of VEGF mRNA expression decreased(P0.05);A.chinesis of large,middle dose group of TGF-β1 mRNA expression decreased(P0.01),and compared with colchicine group,large dose group of of TGF-β1 mRNA expression decreased(P 0.05).Compared with model group,A.chinesis of large,medium and small dose group and colchicine group Bcl-2 protein expression reduce(all is P0.05).But A.chinesis of large,medium and small dose group and colchicine group of Bax protein expression were increased(P 0.05).A.chinesis regulation of VEGF,TGF-β1 may prevent the activation of hepatic stellate cells,liver tissue by up regulating the anti-apoptotic protein Bax and down pro-apoptotic protein Bcl-2 expression,thereby to improve the degree of liver fibrosis.
【Fund】: 陕西省社会发展攻关计划项目(S2011SF1610)
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 2 Hits
1 Yan Zhongsheng; Shell Jiyan; Zhao Shuyuan (Department of Chinese Medicine,the 2nd Affiliated Hospital Xi'an Medical University,Xi'an 710004);Inhibitory effect of Ruangan mixture for hepatic fibrosis in model rats[J];Chinese Journal of Integrated Traditional and Western Medicine On Gastro-spleen;1996-03
2 NIE Danli1,YI Lei2,CUI Dajiang1,YANG Chengzhi1(1.Department of Traditional Chinese Medicine of Second Hosipital,Xi'an Jiaotong University,Xi'an 710004;2.Department of Traditional Chinese Medicine of Shanxi Provincial People's Hospital,Xi'an 710068);Effects of Aralia chinesis L on Proliferation and Function of Fibroblasts[J];Traditional Chinese Drug Research & Clinical Pharmacology;2006-04
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 Xin Guo-hua1,Luo Xu2,Zhang You-lai1,Zeng Yuan-lin1,Wan Zi-yang3 1Department of Burns,3Department of Pharmaceutical Preparation,First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China;2Department of Burns,First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,Zhejiang Province,China;Effect of modified Wuhuang oil on fibroblast growth and proliferation[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2009-50
2 YI Lei,JI Hai-wang,WEI Xue-zhen.Department of TCM of Shanxi Provincial People's Hospital(Xi'an Shanxi,710068)China;Experimental study of Aralia Chinesis L.on hepatic fibrosis[J];Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases;2008-02
3 GUI Da Jiang, NIE Danli, ZHI Mm, et al Department of TCM, the Second Hospital of Xi'an Jiaotong University, Xi'an 710004;Effect and Mechanism of Aralia Chinensis L. in the Treatment of Hepatic Fibrosis in Rats[J];Chinese Journal of Integrated Traditional and Western Medicine On Gastro-spleen;2003-03
4 YI Lei~1,CUI Da-jiang~2,NIE Dan-li~2,YANG Cheng-zhi~2(~1Department of TCM,Shanxi Provincial People's Hospital,Xi'an 710068,China;~2Department of TCM,the Second Hospital of Xi'an Jiaotong University,Xi'an 710004,China);Effects of Aralia Chinesis L.on proliferation and morphology of fibroblasts[J];Chinese Journal of Integrated Traditional and Western Medicine on Digestion;2006-05
5 NIE Danli1,YI Lei2,CUI Dajiang1,YANG Chengzhi1(1.Department of Traditional Chinese Medicine of Second Hosipital,Xi'an Jiaotong University,Xi'an 710004;2.Department of Traditional Chinese Medicine of Shanxi Provincial People's Hospital,Xi'an 710068);Effects of Aralia chinesis L on Proliferation and Function of Fibroblasts[J];Traditional Chinese Drug Research & Clinical Pharmacology;2006-04
6 HUANG Miao,LIU Xin,DONG Lei,SHI Hai-tao,LIU Ya-ping,LIU Chao,ZHANG Xiao-min,MA Han-wei,ZHANG Han-hua,JIA Miao (Department of Digestive Diseases,Second Affiliated Hospital of Xi ’ an Jiaotong University,Xi an 710004,China);Effect of Aralia taibaiensis in treating hepatic fibrosis in rats[J];Chinese Journal of Integrated Traditional and Western Medicine on Digestion;2013-07
7 Ren Meiping;Li Hua;Liu Yan;Zhang Hong;Xiao Shunhan;Tian Ji;Research Center for Drug and Functional Food;Pharmacology Department of Luzhou Medical College;;Study on Aralia saponins in preventing rats liver fibrosis[J];Pharmacology and Clinics of Chinese Materia Medica;2013-04
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Liu Lu, Zhang Mukun, He Lingli Nong Ken Centre Hospital of Guangdong Province (524002);The Diagnostic Significance of Determination of Serum Hepatic Fibrosis Indicators (Ⅳ-C, LN, HA, PCⅢ) Levels in Patients with Liver Diseases[J];Journal of Radioimmunology;2004-01
2 LI Qin, OU Xiao-juan, LI Jia. (Liver Research Center, Beijing Friendship Hospital Affiliate of Capital University of Medical Sciences, Beijing, 100050,China);The contrast study of serum liver fibrosis indexes and liver pathology[J];Chinese Journal of Clinical Hepatology;2004-03
3 Chen F, Chai WM Keywords Liver cirrhosis/diagnosis Liver cirrhosis/therapy Review literature;The progress of diagnosis and therapy for liver fibrosis during the latest three years[J];;1997-02
4 Yang Yx, Kang JY Keywords Liver cirrhosis/diagnosis Liver cirrhosis/etiology Serodiagnosis;Mechanism and serum diagnosis of liver fibrosis[J];;1997-02
5 Shen LY, Li DG, Lu HM Keywords Tetrandrine/pharmacology Salvia miltiorrhiza/pharmacology Cordyceps sinensis/pharmacology Liver cirrhosis/zhong yi yao liao fa;S review of Chinese medicinal herbs rof treatment of liver fibrcsis[J];;1997-02
6 Wang Zhongzhuang,Tang Haifeng*,Su Zhongwu*,Tan Miyan, Hu Jinhong,Li Chenghu* and Yi Yanghua* (Changhai Hospital,Second Military Medical University,Shanghai 200433);Resources Survey of Medicinal Species from Genus Aralia[J];CHINA JOURNAL OF CHINESE MATERIA MEDICA;1997-01
7 Jiang Zao,You Dai-y Nanjing Railway Medical College.;A COMPARATIVE STUDY OF ANTI-FIBROTIC EFFICACIES OF DMPGE2,COLCHICINE AND ZINC SULPHATE OF CCl4-INDUCED ELIVER IN RAT[J];CHINESE JOURNAL OF DIGESTION;1994-03
8 Ma Hong, Wang Baoen, Chen Yiyang, Ma Xuemei f (Liver Diseases Research Centre, Beijing Friendship Hospital, Beijing 100050);The Therapeutic Effect of Astragalus mernbranaceus on Liver Fibrosis Induced by Immunologic Injury in Rats[J];Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases;1997-01
9 ZENG an ping, SUN wei, WANG gang, et al (National Nephrosis Treatment Centor of TCM, the Division of Nephrology Jiangsu Hospital of TCM,Nanjing(210029);The Effects of Jianshen Tablet on Serum O 2 and NO Level Nephrotic rat caused by puromycin[J];CHINA JOURNAL OF BASIC MEDICINE IN TRADITIONAL CHINESE MEDICINE;1999-05
10 Fang Bu-wu;Zhu Qi-gui;Zhu Ji-neng;et al Affiliated Hospital of Hubei College of TCM, Wuhan (430061);Application of Mixture of Reinforcing Qi and Promoting Blood Circulation to Prevent Hepatic Fibrosis due to BSA Immunologic Injury[J];Chinese Journal of Integrated Traditional and Western Medicine;1992-12
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved