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《China Journal of Chinese Materia Medica》 2017-15
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Association rules analysis for exploring combined medication characteristics of Fufang Kushen injection: real-world study based on 49 597 cases

ZHANG Yin;XIE Yan-ming;LI Yan-nan;ZHANG Chang;CHEN Cen;ZHUANG Yan;Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences;Affiliated Hospital of Shandong University of Chinese Medicine;School of Statistics,Renmin University of China;The PLA,Navy General Hospital;  
The present study aimed to analyze the association rules of Fufang Kushen injection in combined medications in the real world based on electrical medical records in hospital information system,and provide reference for its reasonable clinical application.The electrical medical records of the hospitalized patients using Fufang Kushen injection were extracted to analyze the frequency distribution characteristics in combined application with Western medicine,and analyze the specific association rules between these combinations by using Apriori algorithm. A total of 49 597 patients were included in the study,and its common combined medications included5-HT receptor blockers,hepatic protector,antibiotics,chemotherapeutic drugs,immunomodulatory drugs,glucocorticoids,analgetics and proton pump inhibitors. The results revealed that the distribution characteristics in combined application and association combinations of Fufang Kushen injection had specific rules,consistent with the clinical orientation of this drug in treatment of malignant tumor.Such results may provide reference for reasonable application of Fufang Kushen injection in clinical treatment.
【Fund】: 国家“重大新药创制”科技重大专项(2015ZX09501004-001-002 2015ZX09501004-001-009);; 北京市中医药科技发展专项(JJ2014-53);; 中国中医科学院自主选题项目(Z0472 PY1303)
【CateGory Index】: R286
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