Pathomechanisms of pericyte-myofibroblast transition in kidney and interventional effects of Chinese herbal medicine
LIU Ying-lu;SHI Ge;CAO Dong-wei;WAN Yi-gang;WU Wei;TU Yue;LIU Bu-hui;HAN Wen-bei;YAO Jian;Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine;Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School;Department of Nephrology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School;Department of Traditional Chinese Medicine Health Preservation, Second Clinic Medical School,Nanjing University of Chinese Medicine;Division of Molecular Signaling, Department of Advanced Biomedical Research, Interdisciplinary Graduate School of Medicine and Engineering,University of Yamanashi;
In the kidney, pericyte is the major source of myofibroblast(MyoF) in renal interstitium. It is reported that pericyte-myofibroblast transition(PMT)is one of the important pathomechanisms of renal interstitial fibrosis(RIF). Among them, the main reasons for promoting RIF formation include pericyte recruitment, activation and isolation, as well as the lack of pericyte-derived erythropoietin. During the PMT startup process, pericyte activation and its separation from microvessels are controlled by multiple signal transduction pathways, such as transforming growth factor-β(TGF-β)pathway, vascular endothelial growth factor receptor(VEGFR) pathway and platelet derived growth factor receptor(PDGFR) pathway;Blocking of these signaling pathways can not only inhibit PMT, but also suppress renal capillaries reduction and further alleviate RIF. In clinic, many traditional Chinese medicine compound prescriptions, single traditional Chinese herbal medicine(CHM) and their extracts have the clear effects in alleviating RIF, and some of their intervention actions may be related to pericyte and its PMT. Therefore, the studies on PMT and its drug intervention will become the main development direction in the research field of anti-organ fibrosis by CHM.
【Fund】： 国家自然科学基金面上项目(81573903)和国家自然科学基金青年基金项目(81603675);; 江苏省自然科学基金青年基金项目(BK20161046);; 江苏省高校自然科学研究面上项目(16KJB360004);; 南京市医学科技发展基金项目(QRX17042);; 南京市医学科技发展项目(YKK-15057 YKK-16097)
【CateGory Index】： R285.5
【CateGory Index】： R285.5