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Effect of Puerarin on Coronary Collateral Circulation in Dogs with Experimental Acute Myocardial Infarction

Liu Qigong,Wang lin, Lu Zaiying, Li Shusheng and Xiong Yili (Department of Cardiology, Tongji Hospital,Tongji Medical University, Wuhan 430030)  
Objective:To evaluate the effect and mechanism of puerarin on coronary collateral circulation in dogs with experimental acute myocardial infarction. Method:Twelve dogs were randomly divided into puerarin (Gegen su, G) group and control(C) group. the acute myocardial infarction model was built in all dogs.Puerarin or saline was administered for 21 days. Coronary angiography was performed before and after ligating coronary artery. The capillaries and distribution vessel density in tissue sections of myocardium were assessed.Result:Angiography on hour 2 and day 22 after ligating coronary artery revealed significant augmentation of collateral vessels in G group versus controls.Capillaries and distribution vessel density in ischemic and infarctive zone on day 22 revealed statistically significant augmentation in G group versus controls (P0.05 and P0.01). Conclusion:Puerarin might improve the opening and forming of coronary collateral circulation to ischemic myocardium in dogs and protect ischemic myocardium.
【Fund】: 湖北省科委资助
【CateGory Index】: R285.5
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