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《CHINESE JOURNAL OF PATHOLOGY》 1994-01
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The preventive and curative action of fish oil compound on early atherosclerotic lesions in the aortae of diabetic rats

Ni Jin- song; Wu Jia- xiang;Xiao Ren- qiu;et al(Department of Pathology, College of Basic Medicine,Noiman Bethune University of Medical Sciences,Chang Chun 130021)  
50-320g male Wistar rats were divided randomly into three groups:normal control, diabetes mellitus(DM)control and fish oil compound(FOC)treatment groups. The latter two groups were in-duced diabetic by streptozotocin injection. At the end of the third week after injection,the treatment group was fed FOC for 9 weeks.The results showed that FOC could deerease the plasma total cholesterol,triglycerides,low density lipoprotien- cholesterol and very low density lipoprotein cholesterol levels significantly; restrain platelet aggregation; decrease blood pressure and increase atrial natriuretic polypeptide-mRNA content. It was found that the aorta in DM rats had more serious leeions than those in the FOC group.Our study found that FOC could prevent the development of atherosclerosis in DM rats.
【CateGory Index】: R587.1
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