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《CHINESE JOURNAL OF PATHOLOGY》 1994-06
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The inhibition effect of retinoic acid on the invasion and metastasis abilities of metastatic human lung cancer cell subline

Zhu Wei-yong; Zheng Jie;Fang Wei-gang;et al(Department of Pathology , Beijing Medical University, Beijing 100083)  
re-treatment of metastatic human lung cancer cell subline (PGCL3) with all trans retinoic acid(RA)resulted in inhibition of cell growth in vitro and invasion through the reconstituted basement membrane. RA was also noticed to inhibit the experimental metastatic ability of PGCL 3. Data showed that 5/6,3/6 and 2/6 of the nude mice developed lung colonization in the control, the 5μmol/L and the 10 μmol/L RA treated PGCL3 cells respectively.Data from DNA-RNA dot blot hybridization further showed that the 10 μmol/L RA treated cells expressed high levels of the human tissue inhibitors of met-alloproteinases(Timp-1 and Timp-2)in comparing to the untreated cells. These results may help to clarify the mechanism of RA-induced inhibition effect on tumor invasion and metastasis.
【Key Words】: Lung neoplasms Rretinoin Neoplasm invasiveness Genes
【CateGory Index】: R734.202
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