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《Chinese Journal of Traumatology》 2001-04
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A new model of decelerating head injury in rabbits

TAN Yuanfu , CAO Meihong, LIU Yunsheng. * Dept . of Neurosurgery, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China  
Objective To set up an experimental animal model of head injury of deceleration. Methods The decelerating head injury was produced in rabbits by utilizing an impactor consisting of a rotor, elastic strips, a platform and a revolving board. Sixty nine rabbits were used in this experiment: 33 rabbits were for pre experiment to establish the correlation of impact force and brain damage, 36 rabbits were divided into a control group (n=12), a mild injury group (n=12) and a severe injury group (n=12) to elucidate the pathophysiological changes after head injury at different injury levels. Results The physiological responses after impact were observed in all traumatic animals, which showed a sudden rise or reduction of blood pressure, deep and fast breath and apnea, and pain reflects inhibition, etc. The responses were more obvious in the severe injury group than in the mild injury group. The water content of the brain increased 6 h after injury and the intracranial pressure went up 1 6 h after injury in the severe injury group. The pathological lesions were noted at or above the impact force level of (800±50) N. At the severe injury level of (1 100±100) N,there were almost all kinds of lesions, such as skull fracture, brain contusion ( coup injury and contre coup injury),brain stem injury and subdural hematoma. When the impact force rose to or over (1 400±150) N,the animals died of persistent apnea mostly. Conclusions A new practical and simple model of head injury of deceleration in rabbits has been developed with several features similar to the experience in the clinical setting. This model with the same biomechanical mechanism as the clinical head injury of deceleration is quite useful for further study of the pathophysiological mechanisms of head injury, safe measure of abating head injury and investigating the effective therapeutic method for severe head injuries.
【CateGory Index】: R-332
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