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An Experimental Study of Recombinative Artificial Bone of Bone Morphogenetic Protein,Deproteined Bone and Tumour Necrosis Factor α

ZHANG Jian,AN Hong,JIANG Dian ming,et al.Dept.of Orthopedic Surgery,First Affiliated Hospital,Chongqing University of Medical Science,Chongqing 630042.  
One hundred trephined skull bone defects were implanted with combination of bull bone morphogenetic protein (bBMP),bull deproteined bone (bDPB) and recombination of human tumour necrosis factor α (rhTNF α),or combination of bDPB and bDPB alone,or combination of rhTNF α and bDPB,or bDPB alone.Roentgenological and histological changes were observed in 1,2,4,6 and 8 weeks after implantation.The content of 35 S and 45 Ca and ash weight were measured at 10 and 42 days after operation.These investigation demonstrated that the combination of three biomaterials produced higher yields of new bone than that of two or bDPB alone.All implantations were well tolerated to host.TNFα had stimulative effects on bone formation at lower concentration and neovascularization.TNFα was supposed to reduce immune respones as well.We consider that the combination of carrier,inductive factor and growth factor are an ideal model of bioactivity artificial bone.The composite of BMP,DPB and TNFα will be a new valuable biomaterial for bone grafting.(Original article on page 142)
【Fund】: 国家自然科学基金
【CateGory Index】: R318.17
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