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《Chinexe Journal of Pediatrics》 2000-07
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Methicillin-resistant Staphylococcus aureus in Beijing children′s hospital,1993-1998

FANJianfeng ,YANG Yonghong ,TONGYuejuan .DepartmentofMicrobiology,InstituteofPediatrics,BeijingChildren′sHospital AffiliatedtoCapitalUniversityofMedicalSciences,Beijing 10 0 0 45 ,China  
Objective ToexploretheantibioticresistanceepidemiologicalstatusofStaphylococciaureus (SA)isolatedfromBeijingChildren′sHospitalintheperiodbetween 1993 1998.Methods Between 1993and 1998,32 1SAisolateswerecollectedfromchildrenaged 15daysto 15years.Theauthorstested 41,6 4,30 ,135 and 5 1isolatesofSAisolatedin 1993,1994,1995 ,1996and 1998,respectively ,forminimuminhibitory concentration (MIC)to 10kindsofantibioticswithagardilutionmethod .TheseantibioticsincludedpenicillinG , oxacillin,erythromycin ,tetracycline,chloramphenical,clindamycin ,ciprofloxacin ,vancomycin ,rifampinand gentamycin.Results (1)All 32 1isolateswereresistanttopenicillinG .(2 )Therewasobviouslystatistical differenceindrugresistanceratesofSAto 3kindsofantibiotics (P 0 .0 5 )between 1993and 1998.Methicillin resistantStaphylococcusaureus (MRSA)increasedsignificantlyfrom 12 .2 %in 1993to 2 9.4%in 1998.The resistanceofSAtoclindamycinandciprofloxacinincreasedfrom 5 1.2 % ,2 .4%to 72 .5 %and 17.6 % significantly.(3)TheresistanceofSAtoerythromycin ,tetramycinandchloramphenicalduringtheseyearswere 80 % ,70 %and 5 0 %orso ,respectively .(4 )All 32 1isolateswereexquisitelysusceptibletovancomycin , rifampinandgentamycin .(5 )OftheseSA ,6 9(2 1.5 % )isolateswereMRSAand 2 5 2 (78.5 % )were methicillinsensitiveStaphylococcusaureus(MSSA) .(6 )Allthe 6 9MRSAisolatesweremultiresistant,96 .0 %of the 2 5 2MSSAweremultiresistanceisolates .Therewasstatisticallysignificantdifferenceindrugresistanceratesto 5kindsofantibiotics (P 0 .0 5 )betweenMRSAandMSSA .Theseantibioticswereerythromycin ,clindamycin , tetracycline,chloramphenicalandciprofloxacin .TheresistanceratesofMRSAtoerythromycin ,clindamycin , tetramycin ,chloramphenical,andciprofloxacinwere 97.1% ,95 .7% ,81.2 % ,78.3 %and 2 0 .3 % , respectively.TheresistanceratesofMSSAtoerythromycin ,clindamycin ,tetramycin ,chloramphenical,and ciprofloxacinwere 81% ,5 3.2 % ,6 7.1% ,43 .3 %and 7.5 % ,respectively .Conclusion ResistanceofSA tooxacillin ,clindamycinandciprofloxacinhadincreasedfrom 1993to 1998significantlyintheregioninvolved . ThedegreeofresistanceandresistanceregionofMRSAweregettingmoreseriousthanMSSA .Rationalandcorrect useofantibioticsshouldbeemphasized .
【CateGory Index】: R446.5
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