Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinexe Journal of Pediatrics》 2001-08
Add to Favorite Get Latest Update

Immunosuppressive therapy for childhood aplastic anemia

XIEXiaotian ,WANGYaoping ,SHIWei,et al. DepartmentofPediatricHematology/Oncology,TongjiHospital,TongjiUniversity ,Shanghai2 0 0 0 6 5 ,China  
Objective Withstatisticalmethodstoanalyzetheclinicaloutcomesofimmunosuppressive therapy (IS)forchildhoodaplasticanemia (AA) ,especiallyforsevereAA (SAA) .Methods Totally 182cases withchildhoodAAseenduringtherecenttenyearswereincludedinthisstudy.Thepatients′agerangedfrom 1 14 years.Thirtycasesweretreatedwithantithymocyteglobulin (ATG) ,18withcyclosporineA (CsA) ,9withhigh doseimmunoglobulin (HDIG)and 2 1withcombinedIStherapy (2 4immunosuppressants) ,respectively .One hundredandfourcasestreatedwithandrogensbasedtherapywereusedasacontrolgroup .Theclinicaloutcomesof allkindsofIStherapiesweresequentiallysummarizedbyRiditmethod .Results (1)Thetotalresponseratesof combinedISforSAA IandSAA II ,andasingleIStherapy (CsA ,ATGorHDIG)forSAA IIweresignificantly higherthanthatofthecontrolgroup (P 0 .0 5 ) .(2 )IncombinedIStherapygroup ,therewere 5 7.1%ofthe SAAgotcompleteremissionwhile 30 %inthesingleIStherapygroupdidso (P 0 .0 5 ) .Themortalityrateswere 4.8%incombinedISgroupand 2 5 .0 %inthesingleISgroup ,respectively (P 0 .0 5 ) .Thedatashowedthat theclinicalefficacyofcombinedISwassuperiortothatofsingleISatimprovingresponsegradeandsurvival.(3) . Thestudyonpredictivefactorsindicatedthatthereponseratesofthepatientswhohadtheirdiseaseforlessthan 6 monthsbeforetreatmentwithATGorCsA (78.6 %and 90 .0 % )weresignificantlyhigherthanthatofpatientswho hadtheirdiseaseforlongerthan 6months (37.5 % ,P 0 .0 5 ) .(4)IStherapycouldbesafelycarriedoutby carefulprophylaxisandtreatmentofcomplicationsrelatedtothetherapythatwasoneofthemostcriticalconcerns inclinicaltreatmentforAA .(5 )AndrogenscouldincreasetheresponserateofIStherapy .Conclusion ATG , CsAandHDIGwereveryeffectiveintreatmentofchildhoodAA ,especiallyforSAA .CombinedIStherapymay furtherimprovetheresponseandsurvivalrate .Androngenscouldbeaveryuseful supplementin IS therapy for childhood AA .随
【CateGory Index】: R725.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 7 Hits
1 Xiao-Tian XIE, Yao-Ping WANG, Wei SHI. Department of Pediatric Hematology and Oncology, Tongji Hospital, Tongji University, Shanghai 200065, China;Effects of combined immunosupressive therapy on severe aplastic anemia and refractory aplastic anemia in children[J];The Chinese Journal of Contemporary Pediatrics;2004-06
2 LIAO Huo-sheng,PAN Xue-feng,ZENG Xue-lan,et al (Huizhou Muncipal Central Hospital,Guangdong Huizhou 516001,China);High-dose Cyclophosphamide in Treating Childhood Acute Aplastic Anemia[J];Hebei Medicine;2008-09
3 XIE Xiao-tian(Department of Pediatric Hematology and Oncology,Shanghai Tongji Hospital Affiliated to Shanghai Tongji University,Shanghai 200065,China);Standard diagnosis and treatment in childhood aplastic anemia[J];Journal of Clinical Pediatrics;2008-08
4 LI Fuxing,XIE Xiaotian,SHI Wei,SHAO Yuexia,ZHOU Xiaoxun,JIANG Shayi. Department of Pediatrics,Tongji Hospital,Tongji University,Shanghai 200065,China;Efficacy of antithymocyte-globulin in treatment of children with moderate aplastic anemia[J];Shanghai Medical Journal;2010-07
5 ZHOU Xuan,WU Run-hui,DUAN Yan-long(Department of Hematology Center,Beijing Children's Hospital Affiliated to Capital University of Medical Sciences,Beijing 100045,China);Antithymocyte Globulin Combining Cyclosporin in Treatment of Pediatric Severe Aplastic Anemia[J];Journal of Applied Clinical Pediatrics;2007-15
6 XIE Xiao-tian(Department of Pediatrics,Tongji Hospital of Tongji University,Shanghai 200065,China);Diagnosis and Treatment of Children with Aplastic Anemia[J];Journal of Applied Clinical Pediatrics;2009-03
7 HUANG Ke ,HUANG Shao -liang,FANG Jian -pei,ZHONG Feng -yi ,ZHOU Dun -hua,LI Dong -fang,CEN Dan -yang(Department of Pediatrics,The Second Affiliated Hospital,SUN Yat -Sen University,Guangzhou 510120,China);Intensive Immunosuppressive Therapy for Children with Severe Aplastic Anemia[J];Journal of Sun Yat-sen University (Medical Sciences);2004-05
【Citations】
Chinese Journal Full-text Database 2 Hits
1 Xie Xiao-tian;Yao Hui-yue;Gu Mei-yu;et al.(Shanghai Second Medical University, Shanghai200092.);ANALYSIS OF THE THERAPUTIC EFFECTSOF ANTITHYMOCYTE GLOBULIN IN THETREATMENT OF CHILDHOOD APLASTICANEMIA[J];Chinexe Journal of Pediatrics;1994-02
2 Xie Xiaotian; Wang Yaoping; Yao Huiyu; et al(Xing Hua Hospital, Shanghai Second Medical Universi-ty, Shanghai, 200092);HIGH-DOSE INTRAVENOUS IMMUNOGLOBULIN INTREATMENT OF CHILDHOOD ACUTE SEVEREAPLASTIC ANEMIA[J];CHINESE JOURNAL OF HEMATOLOGY;1994-04
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 Xiao-Tian XIE, Yao-Ping WANG, Wei SHI. Department of Pediatric Hematology and Oncology, Tongji Hospital, Tongji University, Shanghai 200065, China;Effects of combined immunosupressive therapy on severe aplastic anemia and refractory aplastic anemia in children[J];The Chinese Journal of Contemporary Pediatrics;2004-06
2 Xie Xiaotian. Liu Zhenrong, Shi Wei, Liu Xingyuan, Yang Jianqian. Department of Pediatric Hematology I Oncology, Gan-quan Hospital affiliated to Medical School of Shanghai Railway University , Shanghai 200065;Combined immunosuppressive therapy of childhood severe aplastic anemia with multiple agents[J];The Journal of clinical Pediatrics;1999-01
3 XIE Xiao-tian(Department of Pediatric Hematology and Oncology,Shanghai Tongji Hospital Affiliated to Shanghai Tongji University,Shanghai 200065,China);Standard diagnosis and treatment in childhood aplastic anemia[J];Journal of Clinical Pediatrics;2008-08
4 XIE Xiao-tian(Department of Pediatrics,Tongji Hospital of Tongji University,Shanghai 200065,China);Diagnosis and Treatment of Children with Aplastic Anemia[J];Journal of Applied Clinical Pediatrics;2009-03
5 Liu Zhuang(Deopartment of Pediatric,the First Affiliated Hospital,Guangxi Medical University,Nanning.);OBSERVATION OF INTRAVENOUS HIGH DOSE IMMUNOGLOBULIN IN THE CHILDREN WITH APLASTIC ANEMIA[J];CHINA CHILD BLOOD;1997-02
6 Sun Lirong,et al. Affiliated Hospital, Medical College, Qingdao University;EVALUATION OF EFFICACY IN CHILDREN WITH RECURRENT CHRONIC APLASTIC ANEMIA WITH MIDDLE DOSE IMMUNOGLOBULIN[J];China Child Blood;2001-06
7 ZHENG Yizhou, CHU Yulin, SHAO Zonghong, et al. Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, Peking Union Medical University, Tianjin 300020, China;Two therapies for acquired severe aplastic anemia in children[J];Chinexe Journal of Pediatrics;2000-02
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Xiao-Tian XIE, Yao-Ping WANG, Wei SHI. Department of Pediatric Hematology and Oncology, Tongji Hospital, Tongji University, Shanghai 200065, China;Effects of combined immunosupressive therapy on severe aplastic anemia and refractory aplastic anemia in children[J];The Chinese Journal of Contemporary Pediatrics;2004-06
2 BAI Xiao-chuan,GUO Hong-wei,YANG Guo-zhen,et al. (Department of Hematology,Affiliated Hospital of Ningxia Med.Coll,Yinchuan 750004,China);The Effectiveness of Home-made Cyclosporin A Regime in the Treatment of Aplastic Anemia[J];West China Medical Journal;2003-03
3 LIANG Jian ying,ZHANG Hong,CHANG Ying jun, et al (Dpartment of Hematology,Second Affiliated Hospital,Suzhou University,Suzhou 215004,China);Detection of serum interleukin-3 level and its clinical significance in aplastic anemia patiens.[J];Journal of Clinical Laboratory Science;2001-04
4 ZHANG Ti, XU Cong gao, LIU Hai peng, et al (Hematology Research Laboratory, Shandong Medical University);EFFECTS OF HUMAN ENDOTHELIAL CELLS AND FOUR CYTOKINES ON GRANULOPOIESIS OF NORMAL SUBJECTS AND PATIENTS WITH APLASTIC ANEMIA[J];ACTA ACADEMIAE MEDICINAE SHANDONG;2000-01
5 FENG Si-zhou1,ZHANG Xue-jun2,WANG Mei1,YANG Dong-lin1,WANG Jin-yu1,JIANG Er-lie1,LIU Chun1,ZHANG Gui-xin1,PAN Ling2,HAN Ming-zhe1 (1.Institute of Hematology and Blood Disease Hospital,Chinese Academy of Medical Sciences & Peking Union of Medical College,Tianjin 300020,China;2.The Second Affiliated Hospital of Hebei Medical University,Shijiazhuang 050000,Hebei, China);Allogeneic hematopoietic stem cell transplantation with HLA-matched sibling and haploidentical donor for multitransfused severe aplastic anemia[J];Biomedical Engineering and Clinical Medicine;2005-04
6 WANG Yi,LU Jun,LI Jie,et al(The Affiliated Children’s Hospital of Suzhou University,Suzhou 215003,China);Effects of ImmunosupressiveTherapy on Severe Aplastic Anemia in Children[J];Chinese Journal of Hemorheology;2005-04
7 XU Chong-Yan Institute of Hematotogy, Hematologic Hospital, Union Medical University of China, Chinese Academy of Medicas Science, Tainjing 300020, China;Immunosuppressive Therapy for Aplastic Anemia--Review[J];Journal of Experimental Hematology;2005-02
8 Lu Jun, Chai Yihuan, Cao Youfu, et al. Department of hematology, Children's hospital affiliated Suzhou university, Suzhou 215003, China;Observation on the early effects of antilymphocyte globulin and cyclosporine A treatment in children with severe aplastic anemia[J];China Child Blood;2005-03
9 ZHENG Yizhou, CHU Yulin, SHAO Zonghong, et al. Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, Peking Union Medical University, Tianjin 300020, China;Two therapies for acquired severe aplastic anemia in children[J];Chinexe Journal of Pediatrics;2000-02
10 Xie Xiao-tian;Yao Hui-yue;Gu Mei-yu;et al.(Shanghai Second Medical University, Shanghai200092.);ANALYSIS OF THE THERAPUTIC EFFECTSOF ANTITHYMOCYTE GLOBULIN IN THETREATMENT OF CHILDHOOD APLASTICANEMIA[J];Chinexe Journal of Pediatrics;1994-02
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 QIU Yi-Ning, BAI Yan, YU Hui, ZHOU Dong-Feng, ZHANG Zhi-Quan, XIAO Yan, JIN Run-Ming. Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan 430022,China;Therapeutic effects of a combination of high-dose immunoglobulin and cyclosporine A in children with aplastic anemia[J];Chinese Journal of Contemporary Pediatrics;2009-01
2 XU Yong-mei, ZHOU Jian-feng, CHAI Jian-nong, ZHANG Min (Department of Pediatrics, The First Hospital of Changshu, Changshu 215500, Jiangsu, China);Aplastic anemia with normal reticulocyte:six cases report[J];Journal of Clinical Pediatrics;2009-10
3 WANG Gao-yan,LI Xue-rong,SUN Li-rong,ZHONG Ren,ZHAO Yan-xia,LU Yuan,SONG Ai-qin,PANG Xiu-ying(Department of Pediatric Hematology,Hospital Affiliated to Medical College,Qingdao University,Qingdao 266003,Shandong,China);Clinical research of combined immunosuppressive therapy on severe aplastic anemia in children[J];Journal of Clinical Pediatrics;2010-08
4 WANG Liang-tuo,ZHANG Xiang-lan,TAN Ri-biao. People's Hospital of Yangjiang City,Yangjiang 529500,Guangdong,CHINA;Expression of T-lymphocyte subsets and its clinical significance in aplastic anemia[J];Hainan Medical Journal;2011-14
5 ZHAO Wei-xing,ZHU Bin.The First People′s Hospital of Guangyuan,Guangyuan,Sichuan 628017,China;The curative effect observation of children,refractory aplastic anemia(RAA) treated by immunosuppressive therapy(IS)[J];Sichuan Medical Journal;2010-08
6 GUO Peng1,HUANG Ning2,GE Lin-fu2(1.West Campus Hospital of Shandong University,Jinan 250012,China;2.Department of Hematology,General Hospital of Chinese PLA,Jinan Command,Jinan 250031,China);Effects of allogeneic peripheral blood stem cell transplantation for severe aplastic anemia in childpatients[J];Journal of Shandong University(Health Sciences);2009-12
7 CHEN Chun(Department of Pediatrics,the Second Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510120,China);Progress of Clinical Diagnosis and Treatment for Aplastic Anemia[J];Journal of Applied Clinical Pediatrics;2007-15
8 ZHAO Xiao-qing,ZHANG Bao-xi,WU Xiao-li(Department of Pediatrics,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China);Expression of Fas/FasL in Children with Aplastic Anemia and Its Clinical Significance[J];Journal of Applied Clinical Pediatrics;2007-15
9 ZHOU Xuan,WU Run-hui,DUAN Yan-long(Department of Hematology Center,Beijing Children's Hospital Affiliated to Capital University of Medical Sciences,Beijing 100045,China);Antithymocyte Globulin Combining Cyclosporin in Treatment of Pediatric Severe Aplastic Anemia[J];Journal of Applied Clinical Pediatrics;2007-15
10 ZOU Wei,FENG Xiao-qin,LI Chun-fu,HE Yue-lin,WU Xue-dong,SHI Lei,LI Na(Department of Pediatrics,Southern Hospital of Southern Medical University,Guangzhou 510515,Guangdong Province,China);Significance of Peripheral T-Lymphocyte Subset Proportions on Predicting Prognosis of Acute Aplastic Anemia Treated with Immunosuppressive Therapy in Children[J];Journal of Applied Clinical Pediatrics;2010-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved