An antibiotic resistance epidemiologic study of group A streptococci isolated from elementary school children in 4 provinces of China
DONG Taiming *, SU Jian, HUANG Zhendong, et al. * Rheumatic Fever Laboratory Guangdong Provincial Cardio Vascular Disease Institute, Guangzhou 510100
Objective To explore the antibiotic resistance epidemiological status of group A streptococci (GAS) isolated from school children in different regions of China. Methods From September 1993 to August 1994, 376 GAS isolates were collected from 9～11 years old healthy school children in 4 provinces of China. The authors tested 97, 81, 84, 62 and 52 isolates of GAS from Jilin province, Northeast China, Sichuan province, Southwest China, Hubei province, Central China, Guangdong province, South China, and rural and urban areas of Guangzhou, respectively for minimum inhibitory concentration (MIC) to 10 kinds of antibiotics with microdilution method. Results (1) All 376 isolates were exquisitely susceptible to penicillin G, cephalothin, nitrofurantoin, norfloxacin, gentamycin and streptomycin. (2) An overall resistance rate was 67.3% in all 376 isolates. The resistance rates were 65.7% to tetracycline, 43.3% to erythromycin, 34.0% to clindamycin, 6.9% to chloramphenicol, 0.5% to ampicillin. There was obviously statistical difference in drug resistance rates to 5 kinds of antibiotics ( P 0.005). (3) There was statistically significant difference ( P 0.005) for the overall drug resistance rates among the 5 areas, which were 94.8% for Jilin province, 83.8% for Guangzhou rural, 58.0% for Chongqing, 50.0% for Hubei, 38.5% for Guangzhou urban, respectively. (4) Multiresistance isolates to tetracycline, erythromycin and chloramphenicol reached 76.3% in Jilin province. Conclusions Penicillin G is still the first choice for the treatment of GAS infections. Beta lactams and quinolones are acceptable alternatives in penicillin allergic individuals. Tetracycline, erythromycin and chloramphenicol are not recommended for treatment of GAS infections and primary or secondery prevention of rheumatic fever at present.
【CateGory Index】： R725.150.5