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《Chinese Journal of Otology》 2014-01
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Meta-analysis of the clinical efficacy of treatment of sudden deafness using hyperbaric oxygen combined with drug in China

KU Wei;LIU Yehai;WU Jing;WANG Qiang;TONG Busheng;DUAN Maoli;Otolaryngology,First Affiliated Hospital of Anhui Medical University;Karolinska University Hospital Department of Clinical Science,Intervention and Technology,Department of Otolaryngology Head and Neck,Department of Neurotology and audiology;  
Objective To evaluate the clinical efficacy of treatment of sudden deafness using hyperbaric oxygen com-bined with drug in recent years.Methods We searched nearly five years Chinese academic journals,Chinese digital library,VIP Information Resource System,Superstar Digital Library,Chinese Biomedical Literature Database,Wanfang databaseabout hyperbaric oxygen therapy combined drug therapy of sudden deafness randomized controlled studies met the inclusioncriteria for the evaluation of methodological literature from 2008 to 2012,and RevMan5.1 software and the quality standardsMeta-analysis of randomized controlled studies were included.Result 20 randomized controlled studies were analyzed,a to-tal of 2554 cases,of which 1,347 cases received hyperbaric oxygen therapy combined with drug treatment as treatment group,in contrast 1,207 cases received drug therapy alone was the control group.We found that the treatment group had a signifi-cant clinical effect than contrast group(P 0.00001),and in addition,the early use of hyperbaric oxygen therapy had bettereffect than the patients with hyperbaric oxygen of treatment at late stage(P 0.00001).Conclusion The application of hyper-baric oxygen therapy combined with drug show better than drug therapy alone was,and the introduction of hyperbaric oxygentherapy,at earlier stage shows better results.
【CateGory Index】: R764.43
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