Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Obstetrics and Gynecology》 2001-05
Add to Favorite Get Latest Update

Loop electrosurgical excision procedure: a valuable method for the treatment of cervical intraepithelial neoplasia

FAN Qingbo *, TAY Sun Kuie,SHEN Keng. *Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China  
Objective To determine the effectiveness and safety of loop electrosurgical excision procedure (LEEP) for the management of cervical intraepithelial neoplasia (CIN) and the significance of positive margins in cervical cone biopsy specimens with the relationship of prognosis. Methods LEEP under local anesthesia and colposcopic guidance was performed in an outpatient of colposcopic clinic. Records of 135 patients treated between Feb 1992 and Jul 1999 were reviewed prospectively. Results The median age of patients in this study was 42 years (range 18~67 years), parity 2 2 times (range 0~8 times). High grade squamous intraepithelial lesion (HGSIL) accounted for majority of diagnosis according to pap smear (65 9%) and colposcopy (75 6%) respectively. The results of LEEP demonstrated negative histology in 7 patients (5 2%), human papilloma virus (HPV) infection in 2 patients (1 5%), CINⅠ in 15 patients (11 1%), HGSIL in 108 patients (80 0%) which including 20 patients (14 8%) of CINⅡ , 88 patients (65 2%) of CINⅢ , microinvasion in 3 patients (2 2%). Clear resection margin of lesion in cervix was noted in 78 (57 8%) patients. Unclear margins were appeared in 57 (42 2%) patients including 21 cases (15 6%) of resection margin positive and 36 cases(26 7%) of resection margin undetermined. HGSIL accounted for the majority (54 cases, 94 7%) in this kind of patients. The residual CIN occurred in 1 patient (4 8%) with the resection margin positive and 3 patients(8 3%) with the resection margin undetermined respectively. In 2 patients (2 6%) with the resection margin clear. Recurrence CIN occurred in 1 patient (4 8%) with the resection margin positive and 2 patients(5 6%) with the resection margin undetermined respectively, none of the patients (0 0%) with the resection margin clear. The overall cure rate in this study was 93 3% after first LEEP done. The residual CIN was identified in 6 (4 4%) patients. The recurrence CIN occurred in 3 (2 2%) patients. Complications of LEEP occurred in 14 1% (19/135) patients in this study. Conclusions LEEP is a kind of effective and safe method for the treatment of cervical intraepithelial neoplasia. The status of resection margin should be concerned. Margin involvement of specimen is the risk factor for residual and recurrence of CIN.
【CateGory Index】: R737.33
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 10 Hits
1 Zhang Xun 1 ,Li Ling 1 ,Zhang Wen-Hua 2 ,Li Shu-Min 2;Evaluation of Cold Knife Conization(CKC)on Diagnosis and Treatment of Cervical Intraepit helial Neoplasia[J];Chinese Journal of Cancer;2003-09
2 Huang Manni Wu Lingying Zhang Wenhua Li Bing An Jusheng Gynecological Oncology of Cancer Hospital,PUMC & CAMS;Clinical analysis of 149 CINⅠ-Ⅱ cases treatment by loop electrosurgical excision procedure[J];Oncology Progress;2007-01
3 BAI Yan-bin,LI Zhi-min,SHAO Yun(Department of Obstetrics and Gynecology,Bengbu Third People's Hospital,Bengbu 233000,China);Clinical observation on loop electrosurgical excision procedure in management of cervical pathological changes[J];Journal of Bengbu Medical College;2006-05
4 WANG Bo wei, LI He lian, ZHAO Shu hua(Dept.of Gynecology and Obstetrics, The Second Hospital, Jilin University, Changchun 130041, China);Histopathological Observation of Cervical Specimens After Thermal Damage from the Loop Electrosurgical Excision Procedure[J];Journal of Jilin University of (Medicine Edition);2003-03
5 JIANG Xing-wei ZHONG Ling,HU Lina,et al.(1.Department of Obstetrics and Gynecology,Second Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400010,China;2.Wsat China Second University Hospital Sichuan University,Chengdu 610041,China);Analyses of causes and managements of bleeding in cervical conization by hysteroscopic electrosection[J];Chongqing Medicine;2007-03
6 LIU Rui.Department of Gynecology and Obstetrics,Luqiao District Hospital of Traditional Chinese Medicine,Taizhou 318050,Zhejiang;Clinical application of loop electrosurgical excision procedure associated with policresulen suppositories in treatment of cervical intraepithelial neoplasia[J];Clinical Medicine;2007-03
7 TIAN Yangshun,SHI Yu,HUI Yanping.(Department of Obstetrics and Gynecology,Xijing Hospital,The Fourth Military Medical University,Xi an 710033,China);The preliminary conclusion of low temperature high frequencyradiosurgical knife in 269 cases of cervical diseases[J];Chinese Journal of Clinical Obstetric and Gynecology;2004-06
8 Zhang Hong, Yu Jiang,Zeng Wei,et al.(The central hospital of 181th of liberation army,the central of women and children,Gynaecology and obstetrics,GuiLin 541002 China);THE CLINICAL EVALUATION OF LEEP IN TREATMENT OF CERVICAL DISEASES[J];Journal of Guangxi Medical University;2005-05
9 ;高频电刀治疗宫颈疾病的疗效分析[J];Contemporary Medicine;2009-30
10 WANG Li-qun(Department of Obstetrics and Gynecology,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,China);Loop electrosurgical excisional procedure for cervical intraepithelial neoplasia in 54 cases[J];Journal of Bengbu Medical College;2009-11
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 LIANG Li zhi, HUANG Xin, LI Mang da,et al.Cancer Center, Sun Yat sen University of Medical Sciences,Guangzhou 510060, P.R. China;Clinical analysis of prognostic factors for 57 patients withcervical carcinoma (CC) younger than thirty years[J];CHINESE JOURNAL OF CANCER;1999-05
2 Zhang Xun 1 ,Li Ling 1 ,Zhang Wen-Hua 2 ,Li Shu-Min 2;Evaluation of Cold Knife Conization(CKC)on Diagnosis and Treatment of Cervical Intraepit helial Neoplasia[J];Chinese Journal of Cancer;2003-09
3 Zhang WenHua Zhang Rong Li Hua Sun YangChun Wu LingYin Bai Ping Department of Gynecology Oncology,Cancer Hospital,CAMS & PUMS,Beijing 100021,China;Initial analysis of management of 23 cases with cervical intraepithelial neoplasia after conization[J];Oncology Progress;2005-01
4 Wu Jialu Li LongyunDepartment of Respiratory Medicine,PUMC Hospital,CAMS & PUMC,Beijing 100730,China;The study of aneusomaty in interphase cells of pleural effusion with FISH[J];Oncology Progress;2005-05
5 Lang Jinghe Ding Xiaoman Department of Obstetrics and Gynecology,PUMC Hospital,CAMS & PUMC,Beijing 100730,China;Current clinical diagnosis and treatment in gynecological oncology[J];Oncology Progress;2006-01
6 LI Qun,TANG Zhao-qian,GUO Su-yang(Department of Gynecologic Oncology,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,China);Treatment of cervical intraepithelial neoplasia and cervical cancer Ⅰa_1 by cervical conization:analysis of 99 cases[J];Journal of Bengbu Medical College;2009-01
7 JIANG CHANG-QING,SONG MEI,WANG XIA, et al (Department of Pathology,Qingdao Municipal Hospital,Qingdao 266011,China);EVALUATION OF LOOP ELECTROSURGICAL EXCISION IN THE DIAGNOSIS AND TREATMENT OF CERVICAL LESIONS[J];Acta Academiae Medicinae Qingdao Universitatis;2007-02
8 WANG Bo wei, LI He lian, ZHAO Shu hua(Dept.of Gynecology and Obstetrics, The Second Hospital, Jilin University, Changchun 130041, China);Histopathological Observation of Cervical Specimens After Thermal Damage from the Loop Electrosurgical Excision Procedure[J];Journal of Jilin University of (Medicine Edition);2003-03
9 XIE Tie nan,FENG Li hua,YU Xiao wei (Department of Obstetrics and Gynecology,First Hospital,Jilin University,Changchun 130021,China);Effects of loop electrosurgical excision procedure on diagnosis and treatment for cervical intraepithelial neoplasia[J];Journal of Jilin University of (Medicine Edition);2004-03
10 Li Guangrong (Guang An Men Hospital, China Academy of TCM, Beijing);The Clinical and Experimental Research of Shiwei Jianmi Shuan on Cervical Carcinoma Blick[J];China Journal of Traditional Chinese Medicine and Pharmacy;1995-04
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Department of Obstetrics and Gynecology,Huaibei Maternal and Child Health Hospital,Huaibei 235000,Anhui HUA Huai-zhen;Diagnosis Value of Cervical Fluid-based Cytology Test Combination Colposcopy Examination for the Cervical Lesion[J];Journal of Anhui Health Vocational & Technical College;2009-01
2 ZHOU Ping (Department of Obstetrics and Gynecology,The First People's Hospital of Huainan,Huainan Anhui 232007,China);Use of high-frequency electric-wave knives in treatment of cervical pathological changes[J];Journal of Bengbu Medical College;2008-04
3 HUANG Jin,YANG Ying(Department of Gynaecology and Obstetrics,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China);Comparation of pathological results of conization and cervix biopsy[J];Chongqing Medicine;2009-08
4 Zhao Wei-ping~1 Zhang Gui-xiang~2 Zhao Xue-dong~2 (1 Chengde Obstetrics and Gynecology's Hospital,Chengde 067000,China) (2 The Affiliated Hospital of Chengda Medical College,Chengda 067000,China);Clinical Efficiency of LEEP in Treatment of 1105 Cases of Chronic Cervical[J];Chinese Journal of Medicinal Guide;2008-02
5 LIU Rui.Department of Gynecology and Obstetrics,Luqiao District Hospital of Traditional Chinese Medicine,Taizhou 318050,Zhejiang;Clinical application of loop electrosurgical excision procedure associated with policresulen suppositories in treatment of cervical intraepithelial neoplasia[J];Clinical Medicine;2007-03
6 TIAN Yangshun,LI Guiyun,HUANG Yanhong,et al. (Department of Obstetrics and Gynecology,Xijing Hospital,Fourth Military Medical University,Xi'an 710033,China);Evaluation of computer-assisted cytologic test in the diagnosis and treatment of cervical diseases[J];Chinese Journal of Clinical Obstetric and Gynecology;2003-05
7 TIAN Yangshun,SHI Yu,HUI Yanping.(Department of Obstetrics and Gynecology,Xijing Hospital,The Fourth Military Medical University,Xi an 710033,China);The preliminary conclusion of low temperature high frequencyradiosurgical knife in 269 cases of cervical diseases[J];Chinese Journal of Clinical Obstetric and Gynecology;2004-06
8 YANG Lingli, ZHU Xiaoping, YANG Huilin, et al.(Shanghai Pudong Women & Children's Health Care Hospital, Shanghai 201206, China);Evaluation of papanicolaou test and liquid-based cytology test in the cervical cancer screening for women in poverty[J];Chinese Journal of Clinical Obstetrics and Gynecology;2009-02
9 CAI Wanqiu ZHONG Huimin Beijiao Hospital Shunde Foshan Guangdong 528311;The Clinical Analysis of Treating Cervical Illhness by High Frequency Scalpel and Povidone Lodine Ointment.[J];International Medicine & Health Guidance News;2006-11
10 LIU Mingxing Jiang Yaling LI Bing Department of Obstetrics and Gynecology of Second Municipal Peopl’es Hospital of Guangzhou, Guangdong 510500, China;LEEP刀治疗宫颈上皮内瘤样病变 69例临床观察[J];International Medicine & Health Guidance News;2006-17
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved