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《Chinese Journal of Obstetrics And Gynecology》 1995-10
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Research on the Rel ationship bctwccn Estrogen Receptor,Progestin Receptor,Cell Prol iferation Associated Antigen in Uterine Leiomyoma and Nucl ear Body Dens ity of Myoma,Serum Reproductive Hormone Concentrations

Wu Ji;Cheng Yunying Nanjing Railway Medical College,Nanjing 210009  
bjective To study the role of sex hormones in the pathogenesis of uterine leiomyoma in order to provide theoretical basis for medical treatment. Methods Estrogen Receptor(ER),progesterone receptor(PR ) and cell proliferation associated antigen(Ki-67)contents of both normal uterine myometrium and leiomyoma were quantitatively anal-ysed by ABC method and image analyser system(IAS ) in 3 0 and 1 9 specimens obtained during hys-terectomy respectively. Nuclear body density were also measured in 8 of them under electronic micro-scope, Serum luteinizing horrnone (LH), follicular stimulating hormone(FSH),estradiol (E_2)and pro-gesterone(P) concentrations were determined by radioimmunoassay in 22 cases on the operation day,21 age-matched normal cycling women served as controls. Results Contents of ER,PR,Ki-67 and the number, volume densities of nuclear body were sig-nificantly higher in leiomyorna than those in normal myometrium(P0. 01,P0. 05). ER,PR con-tents of the two tissues in proliferative phase were greater than those in secretory phase,(P 0. 05 ),while Ki-67 contents were the opposite(P 0.01). ER , PR contents of leiomyoma did not correlate with serum E_02 and P concentrations, but correlate negatively with serum LH and FSH levels(P0. 05 0).Ki-67 contents correlated postively with serum P levels and also showed inverse correlation with serum LH、FSH concentrations (P0.05 ).ER of leiomyoma positively correlated with density of nucl6ear body (P0.05)。Concl usions High ER,PR and Ki-67 contents in leiomyoma,may be the result of local high E_2,P concentrations,and cause growth and development of leiomyoma, High Ki-67 content in secretory phase may indicate that progesterone has a synergistic effect in the pathogenesis of leiomyoma.
【CateGory Index】: R737.33
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1 LI Dong-Mei;WEN Chun-Yan;MA Hong-Xi;College of Special Education,Changchun University;;Analysis on the expressions of Bcl-2 and MMP-1 in recurrent uterine fibroids and their correlation[J];中国妇幼保健;2014-22
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