Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Obstetrics And Gynecology》 1995-10
Add to Favorite Get Latest Update

Research on the Rel ationship bctwccn Estrogen Receptor,Progestin Receptor,Cell Prol iferation Associated Antigen in Uterine Leiomyoma and Nucl ear Body Dens ity of Myoma,Serum Reproductive Hormone Concentrations

Wu Ji;Cheng Yunying Nanjing Railway Medical College,Nanjing 210009  
bjective To study the role of sex hormones in the pathogenesis of uterine leiomyoma in order to provide theoretical basis for medical treatment. Methods Estrogen Receptor(ER),progesterone receptor(PR ) and cell proliferation associated antigen(Ki-67)contents of both normal uterine myometrium and leiomyoma were quantitatively anal-ysed by ABC method and image analyser system(IAS ) in 3 0 and 1 9 specimens obtained during hys-terectomy respectively. Nuclear body density were also measured in 8 of them under electronic micro-scope, Serum luteinizing horrnone (LH), follicular stimulating hormone(FSH),estradiol (E_2)and pro-gesterone(P) concentrations were determined by radioimmunoassay in 22 cases on the operation day,21 age-matched normal cycling women served as controls. Results Contents of ER,PR,Ki-67 and the number, volume densities of nuclear body were sig-nificantly higher in leiomyorna than those in normal myometrium(P0. 01,P0. 05). ER,PR con-tents of the two tissues in proliferative phase were greater than those in secretory phase,(P 0. 05 ),while Ki-67 contents were the opposite(P 0.01). ER , PR contents of leiomyoma did not correlate with serum E_02 and P concentrations, but correlate negatively with serum LH and FSH levels(P0. 05 0).Ki-67 contents correlated postively with serum P levels and also showed inverse correlation with serum LH、FSH concentrations (P0.05 ).ER of leiomyoma positively correlated with density of nucl6ear body (P0.05)。Concl usions High ER,PR and Ki-67 contents in leiomyoma,may be the result of local high E_2,P concentrations,and cause growth and development of leiomyoma, High Ki-67 content in secretory phase may indicate that progesterone has a synergistic effect in the pathogenesis of leiomyoma.
【CateGory Index】: R737.33
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 10 Hits
1 LIU Ya-ping;Department of Obstetrics and Gynecology, Chencang Hospital;;Clinical effect of mifepristone in treatment of uterine leiomyoma[J];临床医学研究与实践;2017-13
2 XU Jing;YAGN Liu;NIE Wei;Department of Obstetrics and Gynecology,Nanyang Central Hospital;;Influence of serum Bcl-2 and Bax in patients with myoma of uterus by Jiang Sanqi[J];中国生化药物杂志;2015-05
3 QIN Ying;The Maternal and Child Care Service Centre of Donggang City in Liaoning Province;;The clinical curative effect analysis of mifepristone in treatment of 51 cases of patients with uterine fibroids[J];中国医药科学;2014-18
4 HAN Li;MA Ru-ping;TANG Jie;QI Yan-li;JING Xiao-ling;Changli People's Hospital of Qinhuangdao City;;Comparison of clinical efficacy of low dose mifepristone combined with Chinese herbal medicine and single low dose mifepristone for hysteromyoma[J];职业与健康;2014-04
5 HAN Li;MA Ru-ping;LONG Yan;Changli People's Hospital of Qinhuangdao City;;Analysis on clinical efficacy of low dose mifepristone for hysteromyoma[J];职业与健康;2013-24
6 JIA Zhi-ling1,WANG Juan1,GUO Chun-yan1, LIU Wei1,LI Qing1,Jirimutu1,2*(1.Key Laboratory of Dairy Biotechnology and Engineering,Ministry of Education, Inner Mongolia Agricultural University,Hohhot 010018,China;2.Inner Mongolia Camel Protection Association,Hohhot 010018,China);THE STUDY OF THE METHOD ABOUT BUILDING THE UTERINE FIBROIDS MODEL[J];内蒙古农业大学学报(自然科学版);2012-Z1
7 GUAN Bing The First Hospital of Henan Provincial Administration,Zhengzhou 450003,China;Clinical observation on Mifepristone and Methyltestosterone in treatment of uterine myoma during perimenopause[J];医药论坛杂志;2013-02
8 LI Xiao-wei,WANG Jian-liu * Department of Obstetrics and Gynecology,Peking University People’s Hospital,Beijing 100044,P. R. China;The etiology of uterine myoma[J];中国计划生育和妇产科;2012-03
9 CAI Jian,CAI Hai-ning,JIANG Bang-rong,WANG Dan-xia(The Ninth Affiliated Hospital of Guangxi Medical University,BeiHai 536000,China);A Study about the Expression of IGFBP-3、ER and PR in Hysteromyoma[J];广西医学;2011-06
10 LI Li-jiao,WU Xiao-chun,KE Xiao-hui,JIANG Lian-ping(Wenzhou City the Second People's Hospital,Wenzhou 325000,Zhejiang,China);Self-Designed Guiling Decation Combined Clinical Analysis of Mifepristone for Treatment[J];中华中医药学刊;2011-02
Chinese Journal Full-text Database 10 Hits
1 LI Dong-Mei;WEN Chun-Yan;MA Hong-Xi;College of Special Education,Changchun University;;Analysis on the expressions of Bcl-2 and MMP-1 in recurrent uterine fibroids and their correlation[J];中国妇幼保健;2014-22
2 XIE Ling-ling;LI Jing;LIN Zhong-qiu;;《NCCN Guidelines Version 1. 2014 Uterine Neoplasms》[J];中国实用妇科与产科杂志;2014-04
3 XIONG Yan;ZHANG Jian;LIU Qin;Tengchong County Maternal and Child Health Hospital;;The Clinical Analysis of 72 Cases of Pregnancy with Uterine Fibroids[J];中国医学创新;2014-04
4 HUANG Feng MAO Lisong ZHANG Jia Department of Gynecology,the People's Hospital of Jimo City in Shandong Province,Jimo 266200,China;The expression and correlation of Bcl-2,IGF-2 proteins in uterine fibroid tissue[J];中国现代医生;2013-13
5 NIU Jian-qing,CHEN Xing-wei,MI Ruo-ran. Department of Obstetrics and Gynecology, Kailuan Hospital,Hebei United University,Tangshan 063000,China; Tianjin Medical University General Hospital, Tianjin 300052,China;Research Progress in the Epidemiological Survey of Uterine Myoma[J];国际妇产科学杂志;2013-01
6 ;子宫肌瘤发病机制研究进展[J];中国实用妇科与产科杂志;2012-12
7 LIN Qing1,LIN Lan2(1.Fujan University of Traditional Chinese Medicine,Fuzhou 350108,Fujian,China; 2.The People's Hospital of Fujan University of Traditional Chinese Medicine,Fuzhou 350004,Fujian,China);Clinical Research on Laws of TCM Syndrome Elements in Hysteromyoma[J];中华中医药学刊;2012-09
8 LI-Li1,SONG Jing-hui2(1.Department of Postgraduate Student 2009,Inner Mongolia Medical College,Hohhot 010059 China;2.Department of Obstetrics and Gynecology,The Affiliated Hospital of Inner Mongolia Medical College,Hohhot 010059 China);Treatment of Uterine Leiomyoma Research Progress[J];内蒙古医学杂志;2012-04
9 MAO Jingyue,LI Caiyun,ZHANG Zhengcheng,SUN Guoquan,HE Jingliang(No.117 Hospital of PLA,Hangzhou City,Zhejiang Province,Hangzhou 310013,China);A comprehensive treatment of uterine fibroids in patients with clinical observation and analysis[J];中国当代医药;2011-04
10 WU Lei,ZHANG Ruihong,SHEN Caiyun,and XU Lei.Department of Obstetrics and Gynecology,Xinjiang Autonomous Regional Corps Hospital,Chinese People's Armed Police Forces,Urumqi 830091,China;Effects of Diphereline on expressions of ER、PR、bcl-2 and bax in endometrium and hysteromyoma[J];武警医学;2011-01
【Secondary References】
Chinese Journal Full-text Database 7 Hits
1 Zhong Zhengmei;Guihang Guiyang Hospital;;Efficacy of low dose mifepristone in the treatment of uterine fibroids[J];中国社区医师;2018-03
2 WANG Ling;WU Qiufeng;Department of Traditional Chinese Medicine, Tianyou Hospital, Wuhan University of Science and Technology;;Effects of momordicosides to P-GSK-3β in rats with adriamycin nephropathy[J];长春中医药大学学报;2017-06
3 LIU Yu-hong;Department of Obstetrics and Gynecology,the People′s Hospital of Xinfeng County;;Clinical effect of low-dose Mifepristone in the treatment of adenomyosis[J];中国当代医药;2017-31
4 GAO Yanming;LIU Xiaofang;LIU Liancheng;Wang Xiulan;WANG Jiuzhen;ZHANG Xiaopang;Department of Obstetrics and Gynecology,Renqiu Municipal Maternal and Child Health Care Hospital;Department of Obstetrics and Gynecology,Cangzhou Municipal Haixing Hospital;Department of Obstetrics and Gynecology,Fengnan Hospital of Traditional Chinese Medicine;;Effet of low dose mifepristone on estrogen,progesterone,uterine volume and tumor volume in patients with uterine fibroid[J];检验医学与临床;2017-20
5 Cheng Ying-ying;The Yiyang People's Hospital;;The Effect of Gongliuqing Capsule on the Serum Levels of IL-22, TNF-α and Sex Hormone in the Treatment of Hysteromyoma[J];中国合理用药探索;2017-10
6 YANG Ye-li;WANG Yong-ying;Department of Gynaecology Haiyan Maternal and Child Health-care Center;;Obserbation on the effect of the long-term low-dose mifepristone on the treatment of hysteromyoma[J];中国生化药物杂志;2017-07
7 CEN Fu-zhu;TAN Guang-ping;LI Jing-jing;MENG Jun;CHEN Sai-qiong;Department of Obstetrics and Gynecology,Fourth Affiliated Hospital of Guangxi Medical University;;Clinical trial of drospirenone and ethinylestradiol tablets and gonadotropin-releasing hormone agonistin in the treatment of patients with uterine muscular glands[J];中国临床药理学杂志;2017-12
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved