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《Chinese Journal of Obstetrics And Gynecology》 1996-10
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TreatmentofUterineLeiomyomabyTwoDifferentDosesofMifepristone

YangYoulin,ZhengShurong,LiKemin,etal.TheFirstAffiliatedHospitalofBeijingMedicalUniversity,Beijing100034  
Objective:Tostudytheresponseofuterineleiomyomatotwodiferentdailydosagesofmifepristone.Methods:Prospectivenonrandomizedclinicaltrialonwomenwithsymptomaticuter-ineleiomyomawasconducted.Twenty-eightpatientsweretreatedwith10mgofmifepristonedailyandfifteenpatientswith20mgdailyfor12weeks,beginningonday1to3ofthemenstrualcycle.Volumechangesofleiomyomaanduterusweremeasuredwithultrasonographybeforetreatment(asbaseline)andmonthlyduringthecourseoftherapy.Bloodsamplesforhemoglobin,liverandrenalfunctionwereobtainedmonthly.Results:Ovarianacyclicitywasinducedinbothgroupsofpatientsgivendiferentdailydosesofmifepristoneanddysmenorrheaandlowabdominalpaindisappeared.Alsymptomsandsignsofanemiawereresolved.Theaveragehemoglobinlevelelevated14~16g/Lmonthly.After12weeksofmifepristonetreatment,theleiomyomavolumedecreasedto41.4%ofbaselineinthe10mgdailydosegroupand43.0%inthe20mgdailydosegroup.Therewasnosignifi-cantdiferencebetweenthetwotreatmentgroups;thesideefectsweresimilar.Conclusion:Mifepri-stoneof10mgdailyisconsideredtobeamoreidealdosagefortreatment.Mifepristonetherapyisin-dicatedinlargerfibroids,and/oraspreoperativemedicationforseverelyanemicpatientsandinperi-menopausalpatientswithsymptomaticfibroids.
【CateGory Index】: R737.33
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