Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Obstetrics And Gynecology》 1997-05
Add to Favorite Get Latest Update

Tissue and Body Fluid Distribution of Antibacterial Agents in Pregnant and Lactating Women

Zhang Yingyuan, Zhang Qing, Xu Zhen, et al. Institute of Antibiotics of Huashan Hospital, Shanghai Medical University, Shanghai 200040  
Objective: To determine the placental transfer and milk excretion of antibacterial agents. Methods: A prospective study was conducted in pregnant and lactating women. The concentrations of 13 agents in tissue and body fluid were determined by bioassay or high performance liquid chromatography method. Results: The results showed that metronidazole, ofloxacin, chloramphenicol, gentamicin and ampicillin crossed blood placental barrier well, the ratio of fetal tissue or amniotic fluid/maternal serum drug concentration was higher than those of the other agents. The penetration of penicillins (except ampicillin) and cephalosporins was poor, but the drug concentrations were still reached therapeutic levels in the most tissues and body fluids. The placental transfer of amikacin, clindamycin and erythromycin was slightly higher than β lactams. The drug concentrations in breast milk was low, except metronidazole and erythromycin, the breast milk levels of the two drugs were more than 100% of maternal serum levels. Conclusion: Based on the results of the study and the consideration of possible adverse effects which may affect both the mother and the developing fetus as well as antibacterial activities of the drugs, the indications and resonable use of the agents in pregnant and lactating period were recommended.
【Fund】: 国家自然科学基金
【CateGory Index】: R978.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 3 Hits
1 Cheng Shaowai,Teng Fenglan,Ma Haoling,et al Liuzhou Central Railway Hospital(Liuzhou 545007);Study on orthogonal table design for the reasonal scheme of administrating antibiotics in cesarean section[J];广西医学;2002-04
2 Deng Feitao, Lu Qiuyun Department of Obstetrics and Gynecology, Xiehe Hospital, Tongji Medical University Wuhan 430022 Department of Obstetrics and Gynecology, Tongji Hospital,Tongji Medical University Wuhan 430030;Interleukin-6 Levels in Maternal Serum, Umbilical Cord Serum and Amniotic Fluid in Patients with Premature Rupture of Membranes and Clinical Implication[J];同济医科大学学报;2000-06
3 LU Hao _ jie, ZHANG Hong, RUAN Zong _ qin, OU Qing _ yu(Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China);Study on the Pharmacokinetics of Metronidazole in Human Milk by Capillary Electrophoresis[J];分析测试学报;2000-04
Chinese Journal Full-text Database 4 Hits
1 LIAO Xiaoling ; GAO Qinghua ; LI Guanxiong ; XU Bing ; LIANG Peihong ; SUN Baozheng ; WANG Qiangwu ;ZHOU Rongxiang ; SUN Chengling( No 421 Hospital of Navy , Guangzhou 510318);Application of Factorial Design on Study of Using Drugs for Preventing Postoperative Infections of Cesarean Sections[J];中国药房;1999-02
2 Zhang Yingyuan, Zhang Qing, Xu Zhen, et al. Institute of Antibiotics of Huashan Hospital, Shanghai Medical University, Shanghai 200040;Tissue and Body Fluid Distribution of Antibacterial Agents in Pregnant and Lactating Women[J];中华妇产科杂志;1997-05
3 ZhengPing,HuangXinghua,WangShuzhen.BeijingObstetricsandGynecologyHospital,Beijing100006;TheChangingTrendofCeseareanSectionRatesin35Years[J];中华妇产科杂志;1996-03
4 Shi Yao-guo;Zhang Qing;Yu Ji-cheng and Zhang-ying-yuan(Institute of Antibiotics,Hua Shan Hospital,Shanghai Medical University,Shanghai 200040)Xu Zheng;Qian Yu-yin;Xia Yian-ping and LiQiao-yun(Obstetrics and Gynecology Hospital,Shanghai Medical Unive;STUDY ON CLINICAL PHARMACOLOGY OF METRONIDAZOLE IN PREGNNT AND BREAST-FEEDING WOMEN[J];中国抗生素杂志;1994-01
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Liu Wei-lin,zhang Lin-jing(Guangxi Institute for Food an Drug Control.Nanning 530021);The Application of Capillary Electrophoresis in Pharmacokinetics[J];中国民族民间医药;2012-03
2 Zeng Minghui,Li Fuxuan,Chen Yao,Long Enwu,Li Ping(Sichuan Academy of Medical Science,Sichuan Provincial People's Hospital,Chengdu,Sichuan,China 610072);Analysis of Prophylactic Antibiotics Use in Perioperative Patients with Type Ⅰ Incision Operation[J];中国药业;2009-17
3 ZENG Ming-Hui,LI Fu-Xuan,CHEN Yao,et al.The People's Hospital of Sichuan,Chengdu,Sichuan 610072,China;Analysis of prophylactic antibiotics use in perioperative patients.[J];四川医学;2008-12
4 ;TNFa在胎膜早破合并宫内感染的作用[J];当代医学(学术版);2008-06
5 WANG Xuan-bin,LIU Ying,LIU Ming,DAI Yuan-ying,ZHOU Xiao-yan,HUANG Kai-yun,TANG Bing,GENG Ji-qing(Department of Pharmacy,Renmin Hospital,Yunyang Medical College,Shiyan,Hubei 442000,China);Content determination of Metronidazole in Metronidazole Beclometasone Cream by High Performance Capillary Electrophoresis[J];郧阳医学院学报;2007-06
6 HUANG Yingfeng,TANG Weibiao,YANG Shaoyu,GU Weili,LUO Hongtu(Dept.of Abdominal Surgery,The First People's Hospital of Guangzhou,Guangzhou510180,China);Analysis of Prophylactic Antibiotics Use in General Surgery during Jul.2005 and Feb.2006[J];中国药房;2006-10
7 ZHANG Ling-wu,YANG Cai-hong.(The Affiliated Hosp. of Ningxia Med. Coll.,Yinchuan 750004,China);Study on perioperative prophylactic antibiotics for cesarean section[J];宁夏医学杂志;2005-08
8 LIN Ying,CHEN Shuming,LI Jun(Department of Clinical Pharmacy, Dongguan People's Hospital of Guangdong Province, Dongguan 523018);Analysis of the Usage of Prophylactic Antibiotics for the Patients in Type Ⅰ and Type Ⅱ Incision Operation[J];中国医院用药评价与分析;2004-02
9 WEI Hong-wei, LEI Zhi-ying, LUO Zhang-wei, QU De-ying, SHI Gui-ling, XIE Li-ling (Affiliated Hospital of Youjiang Medical College for Nationalities, Bose, Guangxi 533000, P.R.China);Interleukin-6 levels in amniotic fluid in pregnant women with premature rupture of fetal membranes[J];右江民族医学院学报;2002-02
10 CHEN Zhaoying.Department of Pharmacy,the Sixth Affiliated Hospital of Guangxi Medical University,Yulin 537000,Guangxi;Analysis of prophylactic antibiotics used in department of gastrointes tinal or glandular organ surgery and hepatobiliary or paediatrics surgery during 2006[J];中国实用医刊;2007-23
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved