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《Chinese Journal of Obstetrics And Gynecology》 1998-08
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A Clinical Control Study on the Treatment of Uterine Leiomyoma with Gonadotrophin Releasing Hormone Agonist or Mifepristone

Zeng Chunying, Gu Meijiao, Huang Hongying. The 4th Municipal Hospital, Wuhan 430033  
Objective To compare the results and side effects in treating uterine leiomyoma with gonadotrophin releasing hormone agonist (GnRHa) or mifepristone. Methods 75 patients with uterine leiomyoma who had clinical symptoms and diagnosed by Bcan were divided into two groups. The GnRHa group (30 patients) was treated by injection of GnRHa 150 μg/day subcutaneously for three months, and the mifepristone group (45 patients) was treated by mifepristone 12.5 mg/day po for three months. Results The clinical symptoms improved obviously in both groups. The volume of leiomyoma reduced 20.0% or more in 90.0% (27/30) of the patients in GnRHa group, while it was 91.1% (41/45) in mifepristone group. However, the recurrent rates were 40.0% and 17.8% in the 2 groups. Conclusion It suggested that mifepristone is a more practical and hopeful drug in treating uterine leiomyoma.
【CateGory Index】: R711.74
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