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Primary Malignant Lymphoma of Bone

HU Yongcheng; LI Guohong; WANG Dianjun; et al. (* TheOrthopaedic Department of the General Hospital of PLA, Beijing 100853)  
Objective To analyze the clinical manifestation and treatment for primary malignantlymphoma of bone. Methods Thirteen patients with the primary site of tumors (spine in 5, ilium in 2,humerus in 2, femur in 2, tibia in l and scapula in l ) were reviewed. The most often presenting symptom waspain. The patients with involved spine commonly had dysfunction of nerve or spinal cord. The abnormalities ofplain radiographs were classified as lytic in 3, sclerotic in 2, and for spine lytic in 4, sclerotic in 3, combi-nation in 3 for extremities. Histologically, all of these patients had diffuse non-Hodgkin lymphoma with Blymphocyte lymphoma in 9, T lymphocyte lymphoma in 4. Nine cases were treated with chemotherapy andirradiation, three cases were treated with chemotherapy only, and one case was treated with irradiation only.Three patients with spinal compression received spinal decompression, one received ilium resection, and onewith humerus pathological fracture received allograft. Results The follow-up range l to 19 years (average,6. 5 years) . Eight patients survive, one died of multiple metastases in the group of nine patients treated withchemotherapy and irradiation, in the group of three patients treated with chemotherapy only, one died of me-diastinum metastases, and one with relapse in soft tissue of low back and received re-resection. One patienttreated with radiation died of bone marrow metastases. Conclusion Primary malignant lymphoma of bone issensitive to chemotherapy and irradiation, the prognosis was satisfactory when treated with a combination ofchemotherapy and irradiation.
【CateGory Index】: 724
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