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《CHINESE JOURNAL OF RADIOLOGY》 1999-08
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Interventional therapies and analysis of prognostic factors in hepatocellular carcinoma with tumor thrombus

ofmainportalvein LIUQi ,TIANJianming ,JIAYuchen ,etal DepartmentofRadiology,Changhai Hospital,Shanghai 2 0 0 4 3 3  
Objective Tostudytheprognosticfactorsinpatientsofhepatocellularcarcinomawithtumor thrombusofmainportalvein ,andtoevaluatetheeffectofvariousinterventionaltherapy Methods onehundred andeighty twopatientswithhepatocellularcarcinomaandtumorthrombusofmainportalveinweregivenmorethan 2timesofinterventionaltreatmentviahepaticartery 2 6caseswithchemotherapyalone (groupA) ,4 2with chemoembolizationusinglipiodol (groupB) ,and 114withchemoembolizationusinglipiodolandgelfoam(group C) Coxproportionalharzardmodelwasusedtoanalysetheprognosticfactorsthatsignificantlyaffectedthesurvival period CumulativesurvivalrateswerecalculatedwiththeKaplan Meiermethod Results ( 1)Univariate analysisshowedthatChild’sclass,tumortype ,tumorsize ,tumoroccupancyrate ,hepaticarterio venousshunt (AVS) ,therapymethod ,changsoftumorsizeandtumorthrombusaftertreatment,andtreatmenttimeswere significantprognosticfactors ;multivariateanalysisshowedthatChild’sclass,tumoroccupancyrates,AVS , therapymethodandtreatmenttimeswerethemostsignificantfactors ( 2 )Thetumorsizereducedby 5 0 %was 0 forgroupA ,2 3 8%forgroupBand 3 2 5 %forgroupC Thedisappearanceratesofmainportalveintumor thrombuswere 7 7% ,2 1 4 %and 3 7 7%forgroupA ,BandCrespectively The 12 ,3 6monthsurvivalrates were 11 5 %and 0forgroupA ,2 1 4 %and 2 4 %forgroupB ,and 3 3 3 %and 3 6%forgroupC respectively Therewasobviousdifferencesamongthethreegroups (P 0 0 0 1) Conclusions Theprognosis ofhepatocellularcarcinomawithtumorthrombusofmainportalveiniscloselyrelatedwiththegeneralconditionof patient,thedegreeoftumorinvasion ,andthemanagement WhenChild’sclassisAandtumorislimitedin extent,thesuperselectivechemoembolizationusinglipiodolandgelfoamismoreeffectiveforprolongingsurvival time
【CateGory Index】: R730.5
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