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《Chinese Journal of Radiology》 2002-04
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The preliminary study of CT cerebral perfusion imaging in transient ischemic attacks

LU Jie, LI Kuncheng, DU Xiangying Department of Radiology, Xuanwu Hospital, the Capital Medical University, Beijing 100053, China  
Objective To probe the application of CT cerebral perfusion imaging on transient ischemic attacks(TIA) Methods Conventional CT and CT cerebral perfusion imaging were performed on 5 normal adults and 20 patients with clinically diagnosed TIA After regular CT examination, dynamic scans of 40 seconds were performed on selected slice (usually on the basal ganglia slice), while 40 ml non ionic contrast material were bolus injected through antecubital vein with These dynamic images were processed with the "Perfusion CT" software package on a PC based workstation Cerebral blood flow (CBF) and time to peak (TP) enhancement were measured within specific regions of the brain on CT perfusion images Quantitative analysis was performed for these images Results A gradient of perfusion between gray matter and white matter was showed on CT perfusion images in normal adults and TIA patients CBF and TP for normal cortical and white matter were 378 2 ml·min -1 ·L -1 , 7 8 s and 112 5 ml·min -1 ·L -1 , 9 9 s, respectively In 20 cases with TIA, persisting abnormal perfusion changes corresponding to clinical symptoms were found in 15 cases with prolonged TP Other 5 cases showed normal results TP of affected side (11 8±4 4) s compared with that of the contralateral side (9 1±3 1) s was significantly prolonged ( t =5 277, P 0 01) The difference of the CBF was not statistically significant ( t =1 892, P =0 074) between affected side [(223 5±38 7) ml· min -1 ·L -1 ] and contralateral side [(229 1±41 4) ml· min -1 ·L -1 ] Conclusion Perfusion CT provides valuable hemodynamic information and shows the extent of perfusion disturbances for patients with TIA
【CateGory Index】: R743
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