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CT guided radioactive seed ~(125)I implantation in treating lung metastasis

ZHANG Fu-jun, WU Pei-hong, GU Yang-kui, ZHAO Ming, ZHANG Liang, TAN Zhi-bin,LIU Da-xin. Department of Imaging and Interventional Radiology, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China  
Objective To investigate the clinical value of CT guided radioactive seed ~(125)I implantation in treating lung metastasis. Methods From October, 2002 to July, 2003, 18 patients (male 10, female 8, median age 56.2) with lung metastasis accepting CT guided radioactive seeds ~(125)I implantation were enrolled in this study. Among these patients, 10 cases had primary liver cancer, 6 cases had primary rectal cancer, and 2 cases had breast cancer. 18 patients totally had 68 metastatic lesions (mean diameter 2.5 cm). Under CT guidance, ~(125)I seeds were implanted into lung metastasis according to TPS. For tumor with remanent width less than 1 cm, plane implantation technique was adopted with ~(125)I seeds of 0.5-0.8 mCi at a distance of 1.0-1.5 cm.Results Among 68 lesions in 18 cases, 36 obtained CR, 17 PR, 10 NC, and 5 PD. The response rate was 77.9%. The side effects occurred during the procedure including few effusions in all patients and pneumothorax in 2 cases with lung compressed less than 30 percent. Blood in sputum occurred in 15 cases 1 week after the procedure and seeds migration occurred in 2 cases during 2 months follow up. WBC decreased slightly in 2 cases 2 weeks after the procedure, but WBC count ≥3×10~9/L. No other severe complications were seen.Conclusion CT guided radioactive seed ~(125)I implantation procedure has good clinical effects in treating lung metastasis with minimal damage and few complications.
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