Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Radiology》 2005-09
Add to Favorite Get Latest Update

Relationship between alternation of cerebral blood flow and formation of brain edema around the hematoma after experimental intracerebral hemorrhage

ZHOU Jian *, GAO Pei-yi, LI Xiao-guang. Beijing Neurosurgical Institute, Beijing 100050, China ( *Now in MR Division, The General Hospital of People′s Armed Police Forces, Beijing 100039, China)  
Objective To investigate the mechanism of brain edema formation around the hematoma and the relationship between the formation of brain edema and the changes of regional cerebral blood flow after intracerebral hemorrhage (ICH) in rats, and to provide experimental basis for the clinical treatment of ICH . Methods Seventy male Sprague-Dawley rats were randomly divided into ICH groups and sham-operated groups. ICH was produced by microinjection of 40 ul fresh autologous blood or saline into the right caudatum. Dynamic CT perfusion imaging was performed, and the parameters of regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV), and mean transit time (MTT) around the hematoma were calculated respectively. Then the rats were sacrificed, and the water content, sodium, potassium, and calcium concentrations were measured respectively. The correlative study between the water content and rCBF and rCBV were carried out. Results The gradient of perihematomal hypoperfusion was revealed on CT perfusion maps in ICH groups. The alternation of rCBF around the hematomas were fluctuated, and rCBF reduction was most pronounced at 1 hour afer ICH, then the rCBF gradually returned, reaching the peaks at 6 hours and 24 hours after ICH, respectively. In the meantime, rCBV reduction around the hematoma was most pronounced at 1 hour after ICH. Then the rCBV gradually increased, and reaching the peak at 24 hours. The water contents were gradually increased in the ipsilateral basal ganglia in the animals sacrificed at 6, 24, and 72 hours. The accumulation of water was at its peak at 24 hours, and remained in the animals sacrificed at the 72 hours. The perihemorrhagic water contents correlated significantly with rCBV surrounding hematomas, r=0.372(one-tailed), P0.05. Conclusion The perihemorrhagic brain edema results from the common effects of the blood-brain-barrier disruption, cytotoxic edema, and the accumulation of osmotically active substances. The rCBF reduction occured in the early stage of ICH and the rCBV compensatory increase play important roles in producing vasogenic edema. Perfusion CT and its parameter analysis is a suitable method in the study of the relationship between the formation of brain edema and the changes of regional cerebral blood flow after intracerebral hemorrhage in vivo.
【Fund】: 国家自然科学基金资助项目(30370427);; 北京市自然科学基金资助项目(7032009)
【CateGory Index】: R743.34
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 2 Hits
1 Chen Suyi,Shi Xueying,Jiang Mingkun,et al Department of Nerology,the Anqing Hosptial of Anhui Medical University,Anqing 246003,China;Observation of the clinical effects of 60 patients with cerebral hemorrhage using micro-invasive paracentesis[J];Anhui Medical Journal;2011-04
2 LI Yang,QU Shao-chun,YU Xiao-feng,XU Hua-li,SUI Da-yuan~*(Department of Pharmacology,School of Pharmacy,Jilin University,Changchun 130021,China);Effect of Acanthopanax senticosus saponins on organ blood flow in anesthetized dogs[J];Journal of Jilin University(Medicine Edition);2006-06
Chinese Journal Full-text Database 1 Hits
1 GAO Pei-yi, LIANG Chen-yang, LIN Yan, YUAN Fang, HU Ling. Department of Neuroradiology, Beijing Neurosurgical Institute, Beijing 100050, China;CT perfusion imaging on the disturbance of regional cerebral microcirculation in a pre-infarction period : an experimental study[J];Chinese Journal of Radiology;2003-08
Chinese Journal Full-text Database 10 Hits
1 YANG Chun,XU Kai Department of Radiology,Affiliated Hospital of Xuzhou Medical College,Xuzhou 221002,China;Investigation of blood-brain barrier damage using delayed scan after CT perfusion imaging[J];Computerized Tomography Theory and Applications;2007-03
2 HU Ling, GAO Pei-yi.Neuroimaging Center,Tiantan Hospital,CapitalUniversity of Medical Sciences,Beijing 100050,China[;Study of local swelling of cerebral astrocytes with CT perfusion and histopathological technique in rats[J];Chinese Journal of CT and MRI;2003-01
3 YANG Chun, XU Kai, LU Xin, et al. Deparment of Radiolgy, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221002, China;Investigation of CT perfusion imaging after gocal cerebral ischemia in rats compared with TTC staining[J];Chinese Journal of CT and MRI;2009-04
4 HU Ling,GAO Pei-yi,YUAN Fang,et al.Neuroimaging Center,Tiantan Hospital,Capital University of Medical Sciences,Beijing 100050,P.R.China;CT Perfusion and Histopathology Research of Local Cerebral Astrocyte Swelling in Rats[J];Radiologic Practice;2005-01
5 LI Ming-li.Jin Zheng-yu,ZHANG Xiao-bo,et al.Department of Radiology,Peking Union Medical College Hospital,Chinese Academy of Medical Science,Beijing 100730,P.R.China;CT Perfusion Study with Stress Test in Chronic Cerebral Ischimic Models[J];Radiologic Practice;2007-09
6 Wang Jiayou, Su Baogui, Pan Sanqiang, He Zhenquan. Department of Anatomy, Basic Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405 China;The effect of electric acupuncture on the capillary and the ultrastructure of neuron in the ischemic penumbra of infracted rats[J];Anatomy Research;2005-04
7 ZHAO Jun-gong, LI Ming-hua, CHENG Ying-sheng, FANG Chun, QIAO Rui-hua. Department of Interventional and Diagnostic Radiology, Affiliated Sixth People's Hospital of Shanghai Jiaotong University, Shanghai 200233, China;Characteristics of diffusion and perfusion-weighted MRI in different cranial infarction areas of acute stroke in a rat model[J];Journal of Interventional Radiology;2005-05
8 YANG Yuhua, ZHU Cuiling, SHI Hao Shandong Provincial Center for Disease Control and Prevention, Jinan 250014, P. R. China;Magnetic Resonance Perfusion Imaging and Stages of RegionalCerebral Perfusion in Pre-infarction Period[J];Journal of Clinical Radiology;2006-05
9 CHEN Jinjun,NING Jingchun Department of Radiology,Chinese Medicine Hospital of Zhaoqing,Zhaoqing,Guangdong Province 526020,P.R.China;The Preliminary Study of CT Cerebral Perfusion Imaging on Basal Ganglia Lacunar Infarction[J];Journal of Clinical Radiology;2009-10
10 GUAN Li-ming, XU Ke, GUO Min, QI Xi-xun, FANG Chang-xing, LIU Shu-li (First Affiliated Hospital, China Medical University, Shenyang 110001, China);CT perfusion C6 cerebral gliomas in rat[J];Journal of China Clinic Medical Imaging;2007-12
Chinese Journal Full-text Database 10 Hits
1 Chen Yasong,Wu Lixin,He Xuelai Department of Internal Medicine,the People's Hospital of Susong County,Anqing 246501;The effect analysis of microinvasive evacuation of hematoma in treatment 24 patients with intracerebral hemorrhage[J];Anhui Medical Journal;2009-07
2 JIANG Hong yu 1,SUI Da yuan 1 ,YU Xiao feng 1,QU Shao chun 1,XU Hua li 1,WANG Zhi cai 2,CHEN Yan ping 2 (1.Department of Pharmacology, School of Pharmacy, Jilin University,Changchun 130021, China; 2.Department of Nature Medical Chemistry, School of Chemistry, Jilin University, Changchun 130021, China);Effects of Acanthopanax senticosus saponins(ASS) on hemorrheology and platelet function in experimental cerebral ischemia rats[J];Journal of Jilin University of (Medicine Edition);2004-03
3 ZHONG Chi, ZHONG Chunjiu, LUO Yumin, WANG Yang, QIN Zhen, SHEN Xinya Department of Neurology, Weifang People's Hospital, Weifang 261041, China;Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China;Institute of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China; Department of Anatomy, Histology and Embryology, Shanghai Medical College, Fudan University, Shanghai 200032, China;The therapeutic effect of the intravenous administration of bone marrow stromal cells for treating transient focal cerebral ischemia in rats[J];Chinese Journal of Neuromedicine;2004-02
4 WU Jia-mi, MA Ling-song, ZHOU Xiang-yang, FEI Shi-zao. Department of Neurology, Yijishan Hospital, Wannan Medical College, Wuhu 241001, China;The role of completement in brain injury after intracerebral hemorrhage[J];Chinese Journal of Neuromedicine;2006-02
5 DU Hong-Jun,HUI Yan-Nian,WANG Yu-Sheng,HAN Quan-Hong,MA Ji-Xian Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China;Caspase-3 activity during daunorubicin induced human retinal pigment epithelium cell apoptosis[J];Journal of The Fourth Military Medical University;2001-07
6 ZHANG Xu Dong, PEI Shi Cheng, LIANG De Sheng, WANG Wei Ming, GE Zhao Ming Department of Neurology, Second Hospital, Lanzhou Medical College, Lanzhou 730030 , China;Observation on penumbra of perihematoma in patient with hypertensive cerebral hemorrhage[J];Journal of The Fourth Military Medical University;2003-03
7 ZHANG Shou-Xin 1, WANG Bing-Ang 2, XIAO Wen 1, LI Gai-Li 1, ZHANG Hong-Bin 1 1Department of Neurology, 2Department of Orthopaedics, Third Hospital of Chinese PLA, Baoji 721004, China;Effects of Radix Astragali injection on expressions of glial fibrillary acidic protein in peri-intracerebral hemorrhage foci[J];Journal of The Fourth Military Medical University;2005-01
8 CHEN Song-lin, ZHANG Cheng, HUANG Wen, YAO Xiao-liDepartment of Neurology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China;Effects of granulocyte colony-stimulating factor on focal cerebral ischemia- reperfusion injury in rats[J];Journal of First Military Medical University;2005-05
9 Wu Jiami, Liu ShengdaDepartment of Neurology, Yi Ji Shan Hospital, Wannan Medical College, WuHu, AnHui (241000);Significance of the Expression of Matrix Metalloproteinase-9 (MMP-9) in Brain Tissue of Rat Models of Experimental Intracerebral Haemorrhage (ICH)[J];Journal of Radioimmunology;2005-05
10 LIN Liang(Postgraduate in Nanjing University of TCM,Jiangsu Nanjing 210029);THE EFFECT OF DIPANGTANG ON THE DEATH OF BRAIN CELLS OF BIG MICE SUFFERED FROM EXPERIMENTAL CEREBRAL HEMORRHAGE[J];Gansu Journal of Traditional Chinese Medicine;2005-03
【Secondary References】
Chinese Journal Full-text Database 5 Hits
1 XIE Bing1,HU Xiao-yun2,FANG Xiang-ming2(1.Dept of Neurology,Gaoyou People’s Hospital,Jiangsu Gaoyou 225600,China;2.Imaging Center,Wuxi People’s Hospital,Jiangsu Wuxi 214023,China);Effects of Hyperbaric Oxygen on Perihematomal Edema in Acute Spontaneous Intracerebral Hemorrhage[J];Suzhou University Journal of Medical Science;2008-06
2 DAI Weimin HUANG Qiang JIE Yuanqing YU Guofeng FAN Xiaofeng Department of Neurosurgery,Quzhou City People's Hospital,Quzhou 324000,China;Analysis of Related Factors Responsible for Brain Edema after Sugery of Traumatic Brain Injury[J];China Modern Doctor;2011-12
3 XIE Zhi-zhong1,LI Jie2,Qin Li1,et al 1 The Institute of Pharmacy & Pharmacology,University of South China(Hengyang 421001) 2 The Second Affiliated Hospital of Sun Yat-Sen University(Guangzhou 510120);Study of the Effect and the Mechanism of Binghuang Decoction on Brain Edema of Intracerebral Hemorrhage[J];Journal of Emergency in Traditional Chinese Medicine;2010-08
4 CHEN Yuyan,LI Hongling, NIU Leilei, et al. The Second Hospital, Hebei Medical University,Shijiazhuang,050000;Effects of different atmosphere absolute hyperbaric oxygen on perihematomal edema and expression of aquaporin-4 in rats with intracerebral hemorrhage[J];Chinese Journal of Rehabilitation Medicine;2013-05
5 ;Clinical observation on treating intracranial hematoma by medical therapy plus minimally invasive surgery[J];Clinical Journal of Chinese Medicine;2013-13
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 Chen Xingrong; Shen Tianzhen (Department of Radiology, Huashan Hospital, Shanghai Medical University, Shanghai 200040);Imaging of Cerebral Infarct[J];CHINESE JOURNAL OF MEDICAL COMPUTED IMAGING;2000-01
2 Gao Peiyi, Lin Yan Department of Neuroradiology, Beijing Neurosurgical Institute, Beijing 100050;Preliminary Study of Cases of TIA with CT Time - to - Peak Perfusion Mapping[J];Chinese Journal of Medical Computed Imaging;2002-01
3 GAO Peiyi, LIN Yan. Center of Neuroimaging, Beijing Neurosurgical Institute, Beijing 100050,China;Personal computer aided mapping and measurement of cerebral perfusion with dynamic CT[J];Chinese Journal of Radiology;2002-01
4 LIANG Chen yang, GAO Pei yi, YUAN Fang, XU Li xin. Beijing Neurosurgical Institute, Beijing 100050, China;Modeling of a controllable acute regional cerebral ischemia in rats and evaluation with CT perfusion imaging and histopathology[J];Chinese Journal of Radiology;2003-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved